Hindle Lab

Updates from the Aerosol Research Group at VCU


Latest publications and patents can be found using Pubmed and Google patent search.

  1.  Aladwani G, Momin MAM, Spence B, Farkas DR, Bonasera S, Hassan A, Hindle M, Longest W: “Effects of Different Mesh Nebulizer Sources on the Dispersion of Powder Formulations Produced with a New Small-Particle Spray Dryer”, Int J Pharm, 2023 Jun 10:123138. doi: 10.1016/j.ijpharm.2023.123138. Epub ahead of print. PMID: 37307962.
  2. Pangeni R, Hassan AAM, Farkas D, Sudarjat H, Longest W, Hindle M, Xu Q: “New Air-Jet Dry Powder Insufflator for High-Efficiency Aerosol Delivery to Rats”, Mol Pharm, 2023 Apr 3;20(4):2207-2216. doi: 10.1021/acs.molpharmaceut.3c00007. Epub 2023 Mar 20.
  3. Kolanjiyil AV, Walenga R, Babiskin A, Golshahi L, Hindle M, Longest W: “Establishing quantitative relationships between changes in nasal spray in vitro metrics and drug delivery to the posterior nasal region”, Int J Pharm, 2023 Mar 25;635:122718. doi: 10.1016/j.ijpharm.2023.122718. Epub 2023 Feb 11.
  4. Pangeni R, Meng T, Poudel S, Sharma D, Hutsell H, Ma J, Rubin BK, Longest W, Hindle M, Xu Q: “Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers”, Int J Pharm, 2023 Mar 5;634:122661. doi: 10.1016/j.ijpharm.2023.122661. Epub 2023 Feb 1.
  5. Spence BM, Longest W, Dutta R, Momin MAM, Strickler S, Hindle M: “In Vitro Evaluation of Nebulized Pharmaceutical Aerosol Delivery to the Lungs Using a New Heated Dryer System (HDS)”, AAPS PharmSciTech, 2022 Nov 30;24(1):10. doi: 10.1208/s12249-022-02460-0.
  6. Farkas D, Thomas ML, Hassan A, Bonasera S, Hindle M, Longest : “Near Elimination of In Vitro Predicted Extrathoracic Aerosol Deposition in Children Using a Spray-Dried Antibiotic Formulation and Pediatric Air-Jet DPI”, Pharm Res, 2023 May;40(5):1193-1207. doi: 10.1007/s11095-022-03316-9. Epub 2022 Jun 27. PMID: 35761163.
  7.  Longest PW, Hassan A, Farkas DR, Hindle M: “Computational Fluid Dynamics (CFD) Guided Spray Drying Recommendations for Improved Aerosol Performance of a Small-Particle Antibiotic Formulation”, Pharmaceutical Research, 39 (2), 295-316, 2022.
  8. Howe C, Momin MAM, Bass K, Aladwani G, Bonasera S, Hindle M, Longest PW: “In Vitro Analysis of Nasal Interface Options for High-Efficiency Aerosol Administration to Preterm Infants”, Journal of Aerosol Medicine and Pulmonary Drug Delivery, Published Online:14 Feb 2022, https://doi.org/10.1089/jamp.2021.00572022
  9. Kolanjiyil AV, Hosseini S, Alfaifi A, Farkas DR, Walenga R, Babiskin A, Hindle M, Golshahi L, Longest PW: “Validating CFD predictions of nasal spray deposition: Inclusion of cloud motion effects for two spray pump designs”, Aerosol Science and Technology 56 (4), 305-322, 2022
  10. Bass K, Momin MAM, Howe C, Aladwani G, Strickler S, Kolanjiyil AV, Hindle M, DiBlasi RM, Longest PW: “Characterizing the Effects of Nasal Prong Interfaces on Aerosol Deposition in a Preterm Infant Nasal Model”, AAPS PharmSciTech 23 (5), 1-18, 2022.
  11. Alfaifi A, Hosseini H, Esmaeili AR, Walenga R, Babiskin A, Schuman T, Longest PW, Hindle M, Golshahi L: “Anatomically Realistic Nasal Replicas Capturing the Range of Nasal Spray Drug Delivery in Adults”, International Journal of Pharmaceutics, 622, 1211858, 25 June 2022, https://doi.org/10.1016/j.ijpharm.2022.121858
  12. Beverlin B, Hindle M, Longest PW, Ferguson M, Kuehl PJ, Lopez A, Montoya D, Anjier A, Gordon NB: “Targeting Lung Tumors using a Novel Inhaled Excipient Enhanced Growth Gemcitabine Dry Powder Formulation”, Respiratory Drug Delivery 2022. Volume 1, 2022: 123-133.
  13. Golshahi L, Alfaifi A, Hosseini S, Esmaeili AR, Hindle M, Longest PW, Schuman T: “Leveraging In Vitro Bioequivalence Tests for Locally-Acting Suspension Nasal Sprays with Three Anatomically Correct Replicas of Human Nasal Airways Representing Intersubject Variability”, Respiratory Drug Delivery 2022. Volume 1, 2022: 37-45.
  14. Howe C, Momin MAM, Farkas DR, Bonasera S, Hindle M, Longest P: “Advancement of the Infant Air-Jet Dry Powder Inhaler (DPI): Evaluation of Different Positive-Pressure Air Sources and Flow Rates”, Pharmaceutical Research, 1-18, 2021
  15. Boc S, Momin MAM, Farkas DR, Longest W, Hindle M: “Performance of Low Air Volume Dry Powder Inhalers (LV-DPI) when Aerosolizing Excipient Enhanced Growth (EEG) Surfactant Powder Formulations”, AAPS PharmSciTech. 22(4):135, Apr 2021.
  16. Boc S, Momin MAM, Farkas DR, Longest W, Hindle M: “Development and Characterization of Excipient Enhanced Growth (EEG) Surfactant Powder Formulations for Treating Neonatal Respiratory Distress Syndrome”, AAPS PharmSciTech. 22(4):136, Apr 2021.
  17. Hochhaus G, Chen M-J, Kurumaddali A, Schilling U, Jiao Y, Drescher SK, Amini E, Kandala B, Tabulov C, Shao J, Seay B, Abu-Hasan MN, Baumstein SM, Winner L, Shur J, Price R, Hindle M, Wei X, Carrasco C, Sandell D, Oguntimein O, Kinjo M, Delvadia R, Saluja B, Lee SL, Conti DS, Bulitta JB: “Can Pharmacokinetic Studies Assess the Pulmonary Fate of Dry Powder Inhaler Formulations of Fluticasone Propionate?”, The AAPS Journal, 2021, 23 (3), 1-14.
  18. Kolanjiyil AV, Hosseini S, Alfaifi A, Hindle M, Golshahi L, Longest PW: “Importance of cloud motion and two-way momentum coupling in the transport of pharmaceutical nasal sprays”, Journal of Aerosol Science, 2021, 156, 105770.
  19. Manniello MD, Hosseini S, Alfaifi A, Esmaeili AR, Kolanjiyil AV, Walenga R, Babiskin A, Sandell D, Mohammadi R, Schuman T, Hindle M, Golshahi L: “In Vitro Evaluation of Regional Nasal Drug Delivery Using Multiple Anatomical Nasal Replicas of Adult Human Subjects and Two Nasal Sprays”, International Journal of Pharmaceutics, 120103
  20. Farkas D, Bonasera S, Bass K, Hindle M, Longest PW: “Advancement of a Positive-Pressure Dry Powder Inhaler for Children: Use of a Vertical Aerosolization Chamber and Three-Dimensional Rod Array Interface”, Pharmaceutical Research 2020, 37 (9), 1-14.
  21. Howe C, Hindle M, Bonasera S, Rani V, Longest PW: “Initial Development of an Air-Jet Dry Powder Inhaler for Rapid Delivery of Pharmaceutical Aerosols to Infants”, Journal of aerosol medicine and pulmonary drug delivery.
  22. Dutta R, Spence B, Wei X, Dhapare S, Hindle M, Longest PW: “CFD Guided Optimization of Nose-to-Lung Aerosol Delivery in Adults: Effects of Inhalation Waveforms and Synchronized Aerosol Delivery”, Pharmaceutical Research 2020, 37 (10), 1-18.
  23. Bass K, Farkas D, Hassan A, Bonasera S, Hindle M, Longest PW: “High-efficiency dry powder aerosol delivery to children: Review and application of new technologies”, Journal of Aerosol Science, 105692.
  24. Hassan A, Farkas D, Longest PW, Hindle M: “Characterization of excipient enhanced growth (EEG) tobramycin dry powder aerosol formulations”, International Journal of Pharmaceutics, 120027.
  25. Longest W, Farkas D, Bass K, Hindle M. Use of Computational Fluid Dynamics (CFD) Dispersion Parameters in the Development of a New DPI Actuated with Low Air Volumes. Pharm Res. 2019 May 28;36(8):110, DOI: 10.1007/s11095-019-2644-1.
  26. Longest W, Spence B, Hindle M. Devices for Improved Delivery of Nebulized Pharmaceutical Aerosols to the Lungs. J Aerosol Med Pulm Drug Deliv. 2019 Jul 9. doi: 10.1089/jamp.2018.1508. [Epub ahead of print]
  27. Wei X, Hindle M, Kaviratna A, Huynh BK, Delvadia RR, Sandell D, Byron PR. In Vitro Tests for Aerosol Deposition. VI. Realistic Testing with Different Mouth-Throat Models and In Vitro-In Vivo Correlations for a Dry Powder Inhaler, Metered Dose Inhaler, and Soft Mist Inhaler. J Aerosol Med Pulm Drug Deliv. 2018 Jun 7. DOI: 10.1089/jamp.2018.1454.
  28. Spence BM, Longest W, Wei X, Dhapare S, Hindle M. Development of a High-Flow Nasal Cannula and Pharmaceutical Aerosol Combination Device. J Aerosol Med Pulm Drug Deliv, 21 Mar 2019, DOI: 10.1089/jamp.2018.1488.
  29. Farkas D, Hindle M, Longest PW. Efficient Nose-to-Lung Aerosol Delivery with an Inline DPI Requiring Low Actuation Air Volume. Pharm Res. 21 Aug 2018;35(10):194. DOI: 10.1007/s11095-018-2473-7.
  30. Bass K, Boc S, Hindle M, Dodson K, Longest PW. High-Efficiency Nose-to-Lung Aerosol Delivery in an Infant: Development of a Validated Computational Fluid Dynamics Method. J Aerosol Med Pulm Drug Deliv. 15 Dec 2018 https://doi.org/10.1089/jamp.2018.1490
  31. Dhapare S, Boc ST, Spence B, Bass K, Longest P, Hindle M. Overcoming the Challenges of Aerosol Delivery to Infants During Non-invasive Ventilation. RDD Asia 2018, Volume 1, 2018: 93-102.
  32. Longest PW, Bass K, Dutta R, Rani V, Thomas ML, El-Achwah A, Hindle M. Use of computational fluid dynamics deposition modeling in respiratory drug delivery. Expert Opinion Drug Delivery. 2018; 16 (1): 7-26
  33. Dhapare S, Boc ST, Spence B, Bass K, Longest P, Hindle M. Overcoming the Challenges of Aerosol Delivery to Infants During Non-invasive Ventilation. RDD Asia 2018, Volume 1, 2018: 93-102.
  34. Farkas D, Hindle M, Longest PW. Application of an inline dry powder inhaler to deliver high dose pharmaceutical aerosols during low flow nasal cannula therapy. Int J Pharm. 5 May 2018;546 (1-2):1-9. PMID: 29733972 DOI: 10.1016/j.ijpharm.2018.05.011
  35. Huynh BK, Traini D, Farkas DR, Longest PW, Hindle M, Young PM. The Development and Validation of an In Vitro Airway Model to Assess Realistic Airway Deposition and Drug Permeation Behavior of Orally Inhaled Products Across Synthetic Membranes. J Aerosol Med Pulm Drug Deliv. 1 Apr 2018;31 (2):103-108. PMID: 28880765 DOI: 10.1089/jamp.2017.1400
  36. Wei X, Hindle M, Delvadia RR, Byron PR: In vitro tests for aerosol deposition. V: using realistic testing to estimate variations in aerosol properties at the trachea. J Aerosol Med Pulm Drug Deliv. 23 Mar 2017; PMID: 28332899 DOI: 10.1089/jamp.2016.1349.
  37. Walenga RL, Longest PW, Kaviratna A, Hindle M: Aerosol drug delivery during noninvasive positive pressure ventilation: effects of intersubject variability and excipient enhanced growth. J Aerosol Med Pulm Drug Deliv. 2017; 30(3): 190-205.
  38. Longest PW, Hindle M: Small airway absorption and microdosimetry of inhaled corticosteroid particles after deposition. Pharm Res. 22 Jun 2017; PMID: 28643237 DOI: 10.1007/s11095-017-2210-7.
  39. Farkas D, Hindle M, Longest PW: Development of an Inline Dry Power Inhaler That Requires Low Air Volume. J Aerosol Med Pulm Drug Deliv. 20 Dec 2017. doi.org/10.1089/jamp.2017.1424
  40. Azimi M, Williams G, Golshahi L, Longest PW, Hindle M: Evaluating simulated patient use in realistic nasal airway models for in vitro characterization of nasal spray products. Inhalation. Feb 2018
  41. Hindle M, Wei X, Spence B, Golshahi L, Longest P. Aerosol Therapy During Non-invasive Ventilation: Challenges and Opportunities. Respiratory Drug Delivery 2018. Volume 1, 2018: 137-148.
  42. Holbrook L, Hindle M, Longest PW: In vitro assessment of small charged pharmaceutical aerosols in a model of a ventilated neonate. Journal of Aerosol Science. 2017; 110: 25-35.
  43. Azimi M, Longest P, Hindle M: “Towards Clinically Relevant In Vitro Testing of Locally Acting Nasal Spray Suspension Products”, RDD Europe 2015. 1: 121-130, 2015.
  44. Rygg A, Hindle M, Longest PW: Linking Suspension Nasal Spray Drug Deposition Patterns to Pharmacokinetic Profiles: A Proof-of-Concept Study Using Computational Fluid Dynamics. J Pharm Sci. 2016;105(6):1995-2004.
  45. Longest PW, Tian G, Khajeh-Hosseini-Dalasm N, and Hindle M: Validating Whole-Airway CFD Predictions of DPI Aerosol Deposition at Multiple Flow Rates. J Aerosol Med Pulm Drug Deliv. 2016; doi:10.1089/jamp.2015.1281.
  46. Rygg A, Hindle M, Longest PW: Absorption and Clearance of Pharmaceutical Aerosols in the Human Nose: Effects of Nasal Spray Suspension Particle Size and Properties. Pharm Res. 2016;33(4):909-21.
  47. Longest PW, Rygg A, Hindle M: Bioequivalence Testing: Can Systemic Pharmacokinetic Profiles from Corticosteroid Nasal Sprays Be Used to Elucidate Local Drug Deposition within the Nose? Respiratory Drug Delivery 2016. 1: 175-184.
  48. Farkas, D., Hindle, M. Longest, P.W. Characterization of a New High-Dose Dry Powder Inhaler (DPI) Based on a Fluidized Bed Design. Annals of Biomedical Engineering. 2015. 43(11), 2804-2815. doi: 10.1007/s10439-015-1335-2
  49. Holbrook, L., Hindle, M., Longest, P.W. Generating Charged Pharmaceutical Aerosols Intended to Improve Targeted Drug Delivery in Ventilated Infants. Journal of Aerosol Science. 2015. 88, 35-47. doi:10.1016/j.jaerosci.2015.05.015
  50. Tian, G., Hindle, M., Lee, S., Longest, P.W. Validating CFD Predictions of Pharmaceutical Aerosol Deposition with In Vivo Data. Pharmaceutical Research. 2015. doi:10.1007/s11095-015-1695-1.
  51. Golshahi, L., Longest, P.W., Holbrook, L., Snead, J., Hindle, M. Production of Highly Charged Pharmaceutical Aerosols Using a New Aerosol Induction Charger. Pharmaceutical Research. 2015. doi:10.1007/s11095-015-1682-6
  52. Longest, P.W., Golshahi, L., Behara, S.R.B., Tian, G., Farkas, D.R., Hindle, M. Efficient Nose-to-Lung (N2L) Aerosol Delivery with a Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2015. doi:10.1089/jamp.2014.1158.
  53. Golshahi, L., Walenga, R.L., Longest, P.W., Hindle M. Development of a Transient Flow Aerosol Mixer-Heater System for Lung Delivery of Nasally Administered Aerosols Using a Nasal Cannula. Aerosol Science and Technology., 2014. 48 (10), 1009-1021. doi:10.1080/02786826.2014.954029
  54. Walenga, R.L., Tian, G., Hindle, M., Yelverton, J., Dodson, K., Longest, P.W., Variability in Nose-to-Lung Aerosol Delivery. Journal of Aerosol Science., 2014. 78, 11-29. doi:10.1016/j.jaerosci.2014.08.003.
  55. Golshahi, L., Longest P.W., Azimi, M., Syed, A., Hindle M. Intermittent Aerosol Delivery to the Lungs during High Flow Nasal Cannula Therapy. Respiratory Care., 2014 59 (10), 1476-1486. doi: 10.4187/respcare.02903
  56. Tian, G., Hindle, M., Longest, P.W. Targeted Delivery of Nasally Administered Aerosols. Aerosol Sci. Tech., 2014. 48 (4), 434-449. doi:10.1080/02786826.2014.887829.
  57. Behara, S.R., Longest, P.W., Farkas, D.R., Hindle, M. Development of High Efficiency Ventilation Bag Actuated Dry Powder Inhalers. Int. J. Pharm. 2014.465 (1), 52-62. doi:10.1016/j.ijpharm.2014.01.043.
  58. Behara, S.R., Longest, P.W., Farkas, D.R., Hindle, M. Development and Comparison of New High-Efficiency Dry Powder Inhalers for Carrier-Free Formulations. J. Pharm Sci., 2014.103 (2), 465-477. doi:10.1002/jps.23775.
  59. Longest, P.W., Azimi, M., Golshahi, L., Hindle, M. Improving Aerosol Drug Delivery During Invasive Mechanical Ventilation with Redesigned Components. Respiratory Care., 2013. 59(5): 686-98. doi:10.4187/respcare.02782.
  60. Longest, P.W., Azimi, M., Hindle, M. Optimal Delivery of Aerosols to Infants During Mechanical Ventilation. J Aerosol Med Pulm Drug Deliv. 2013.doi:10.1089/jamp.2013.1077.
  61. Behara, S.R., Farkas, D.R., Hindle, M., Longest, P.W. Development of a High Efficiency Dry Powder Inhaler: Effects of Capsule Chamber Design and Inhaler Surface Modifications. Pharm Res. 2013. DOI:10.1007/s11095-013-1165-6.
  62. Golshahi, L., Tian, G., Azimi, M., Son, YJ, Walenga R, Longest PW, Hindle M. The use of condensational growth methods for efficient drug delivery to the lungs during noninvasive ventilation high flow therapy. Pharm Res. 2013 Nov;30(11):2917-30. doi: 10.1007/s11095-013-1123-3.
  63. Longest, P.W., Golshahi, L. and Hindle, M. Improving Pharmaceutical Aerosol Delivery during Noninvasive Ventilation: Effects of Streamlined Components. Annals of Biomedical Engineering. 2013; 41(6): 1217-1232.
  64. Son, YS, Longest, P.W., Tian, G. and Hindle, M. Evaluation and Modification of Commercial Dry Powder Inhalers for the Aerosolization of a Submicrometer Excipient Enhanced Growth (EEG) Formulation. Eur J Pharm Sci, 2013; 49(3): 390-399.
  65. Longest, P.W., Son, YS., Holbrook, L.T. and Hindle, M. Aerodynamic Factors Responsible for the Deaggregation of Carrier-Free Drug Powders to form Micrometer and Submicrometer Aerosols. Pharm. Res. 2013 30(6): 1608-1627, 2013.
  66. Son, YS, Longest, P.W. and Hindle, M. Aerosolization Characteristics of Dry Powder Inhaler Formulations for the Enhanced Excipient Growth (EEG) Application: Effect of Spray Drying Process Conditions on Aerosol Performance. Int J. Pharm. 2013; 443(1-2): 137-45.
  67. Tian, G., Longest, P.W., Li, X. and Hindle, M. Targeting Aerosol Deposition to and within the Lung Airways using Excipient Enhanced Growth. J Aerosol Med Pulm Drug Del. 2013. DOI: 10.1089/jamp/2012.0997.
  68. Longest, P.W., Walenga, R., Son, YS. and Hindle, M. High Efficiency Generation and Delivery of Aerosols through Nasal Cannula during Noninvasive Ventilation. J Aerosol Med Pulm Drug Del. 2012. DOI: 10.1089/jamp/2012.1006
  69. Hindle, M. and Longest, P.W. Quantitative Analysis and Design of a Spray Aerosol Inhaler. Part 2: Improvements in Mouthpiece Performance. J Aerosol Med Pulm Drug Del. 2012; DOI: 10.1089/jamp.2012.0995
  70. Laing, A. Thakkar, J.N., Hindle, M. and Desai, U.R. Dynamic affinity chromatography in the separation of sulfated lignins binding to thrombin. J. Chromatog. B 2012; 908: 45-51.
  71. Longest, P.W., Tian G., Li, X, Son, Y-S and Hindle, M. Performance of Combination Drug and Hygroscopic Excipient Submicrometer Particles from a Softmist Inhaler in a Characteristic Model of the Airways. Annals of Biomedical Engineering 2012; 40(12): 2596-2610, 2012.
  72. Delvadia, R.R., Longest, P.W., Hindle, M., and Byron, P.R. In vitro tests for aerosol deposition. III: Effect of inhaler insertion angle on aerosol deposition. J. Aerosol Med Pulm Drug Del. 26(3): 145-156, 2013.
  73. Longest, P.W., Tian G., Delvadia, R.R., and Hindle, M., Development of a stochastic individual path (SIP) model for predicting the tracheobronchial dose of pharmaceutical aerosols: Effects of turbulence, polydisperse aerosol size, and evaluation of multiple lung lobes. Aerosol Sci Tech 2012; 46: 1271-1285.
  74. Longest, P.W., Tian, G., Son, Y-S., Li, X., and Hindle, M. Engineered Drug Targeting to the Lungs: Ensuring Growth and Deposition of Submicrometer Aerosols Through Device Design and Formulations. Respiratory Drug Delivery 2012 (eds. Dalby, R.N., Byron, P.R., Peart, J., Suman, J.D. and Farr, S.J.) Davis Heathcare International, River Grove, IL., Volume 1, 61-69, 2012.
  75. Delvadia, R.R., Hindle, M., Longest, P.W. and Byron, P.R. In Vitro Tests for Aerosol Deposition. II: IVIVCs for Different Dry Powder Inhalers in Normal Adults. J. Aerosol Med Pulm Drug Del. 26(3): 138-144, 2013, DOI:10.1089/jamp.2012.0975.