Hindle Research Group
Our pharmaceutical aerosol development laboratories are located on the MCV campus of Virginia Commonwealth University. This interdisciplinary group works in collaboration with Dr Worth Longest (Department of Mechanical Engineering) to combine computational fluid dynamics (CFD) and design engineering to produce novel pharmaceutical aerosol drug delivery systems. Current projects are developing a high efficiency handheld dry powder inhaler and devices for improving aerosol delivery during non-invasive ventilation using controlled condensation growth methods.
Our groups have also focused on the development of innovative in silico and in vitro methods to assess the pulmonary deposition from commercial inhalers using realistic oropharyngeal models. Other projects are investigating nanoparticle formation techniques for inhalation and nasal drug delivery and the delivery of antibiotics by inhalation.
Our group has received funding from the National Institutes of Health, the Food and Drug Administration and the Pharmaceutical Industry.
Currently funded projects from the NIH:
5 R01 HD087339 02 – HIGH EFFICIENCY INHALATION DELIVERY OF TOBRAMYCIN FOR CHILDREN WITH CYSTIC FIBROSIS, NICHD, LONGEST AND HINDLE (PIs)
5 R01 HL107333 06 – HIGH EFFICIENCY AEROSOL DELIVERY USING THE EXCIPIENT ENHANCED GROWTH CONCEPT: A HUMAN PROOF OF CONCEPT STUDY NHLBI, LONGEST AND HINDLE (PIs)
1 R01 HL139673 01 – HIGH EFFICIENCY DELIVERY OF SURFACTANT AEROSOLS TO INFANTS WITHOUT INTUBATION, NHLBI, LONGEST AND HINDLE (PIs)