VCU SOD congratulates Dr Andrew Yeudall our first Fellow of the Royal Society of Pathologists
Dr Yeudall has published over 70 papers, reviews and book chapters.
The examinations committee of the Royal College of Pathologists assessed these works and the impact they have had in oral pathology. Three areas of research that were considered are:
- Papillomaviral carcinogenesis – human papillomavirus (HPV) is now known to cause anogenital cancers and is implicated in the development of a small subset of head and neck cancers
- p53 – a protein that regulates the cell cycle and is involved in preventing cancer, but some alterations in its structure can actively drive cancer development
- Cell cycle and motility – alterations in these processes can lead to cancer development and metastasis
With his admittance into the Royal College, Dr Yeudall has joined an elite group of only 64 F.R.C.Path in Oral Pathology worldwide and one of only 5 based in the USA.
Dr Yeudall’s research aims to identify mechanisms through which head and neck squamous cell carcinomas (HNSCC) develop and progress to form metastatic cancers and how they become resistant to conventional therapeutics. His previous work has shown enhanced expression of the signal transducer EPS8 in HNSCC, inhibition of which blocks tumor growth and triggers mesenchymal-to-epithelial transition of tumor cells. His current work is directed towards understanding how EPS8 is deregulated in oral cancer using cell-based assays and a transgenic model. The long term goal is to develop novel targeted therapeutics that will complement existing treatments to eradicate oral cancer.
If you are interested in Dr Yeudall’s research you can read two of his reviews here:
Chemokines and squamous cancer of the head and neck: targets for therapeutic intervention? Yeudall WA, Miyazaki H. Expert Rev Anticancer Therapy. 7, 351-360 (2007).
Cell cycle de-regulation in head and neck cancer. Yeudall WA, Wrighton KH. In: Head and Neck Cancer. Eds. Ensley JF, Lippman, S, Jacobs, J, Gutkind, JS. Academic Press. New York. pp101-116 (2003).
Or see his publications at PubMed.
Dr Yeudall received his BSc in Biochemistry, BDS and PhD from the University of Glasgow. After postdoctoral training at the NIDCR and faculty positions in the Universities of Bristol and London, he joined VCU School of Dentistry in 2003.
Categories Research