Laura Ellwein Fix, PhD

Applied Dynamics in Cardiorespiratory Physiology

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Publications

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Submissions Under Review

19. Foster R, Ellwein Fix L. (2022) Thoracoabdominal asynchrony in a virtual preterm infant: computational modeling and analysis. (Submitted to Am J Physiol Lung Cell Mol Physiol)

Refereed Publications and Proceedings

18. Ellwein Fix, Laura; Filippas, Afroditi; Brucal-Hallare, Maila; and Segal, Rebecca (2022) “Improving Student Knowledge Transfer between Mathematics and Engineering Courses through Structured Cross-disciplinary Collaboration: A SUMMIT-P Initiative,” Journal of Mathematics and Science: Collaborative Explorations: Vol. 18: No. 1, Article 4. https://scholarscompass.vcu.edu/jmsce_vamsc/vol18/iss1/4

17. Colebank MJ, Paun M, Qureshi MU, Chesler N, Husmeier D, Olufsen MS, Ellwein Fix L. (2019) Influence of image segmentation on one-dimensional fluid dynamics predictions in the mouse pulmonary arteries. J R Soc Interface,
https://royalsocietypublishing.org/doi/10.1098/rsif.2019.0284 (IF= 4.118)

16. Qureshi MU, Colebank MJ, Paun ML, Ellwein Fix L, Chesler N, Haider MA, Hill NA, Husmeier D, Olufsen MS. (2019). Hemodynamic assessment of pulmonary hypertension in mice — a model-based analysis of the disease mechanism. Biomech Model Mechanobiol, 18(1):219-243, https://doi.org/10.1007/s10237-018-1078-8 (IF=3.323)

15. Ellwein Fix L, El Khoury J, Moores R Jr., Linkous L, Brandes M, Rozycki H. (2018). Theoretical open-loop model of respiratory mechanics in the preterm neonate. PLoS ONEhttps://doi.org/10.1371/journal.pone.0198425  (IF=2.806)

14. Ellwein L, Samyn M, Danduran M, Schindler-Ivens S, Liebham S, LaDisa Jr. JF. (2017) Toward translating near-infrared spectroscopy oxygen saturation data for the non-invasive prediction of spatial and temporal hemodynamics during exercise. Biomech Model Mechanobiol, 16(1):75-96. https://doi.org/10.1007/s10237-016-0803-4 (IF=3.323)

13. Ellwein L, Marks DS, Migrino RQ, Foley WD, Sherman S, LaDisa JF Jr. (2016) Image-based quantification of 3-D morphology for bifurcations in the left coronary artery: application to stent design. Cathet Cardiovasc Intervent, 87(7):1244-55. https://doi.org/10.1002/ccd.26247 (IF=2.602)

12. Ford Versypt AN, Makrides E, Arciero J, Ellwein L, Layton AT. (2015) Bifurcation study of blood flow control in the kidney. Math Biosci, 263:169-179. https://doi.org/10.1016/j.mbs.2015.02.015 (IF=1.246)

11. Quam DJ, Gundert TJ, Migrino RQ, Otake H, Ellwein L, Hayden P, LaDisa JF, Jr. (2015) Immersive visualization for enhanced computational fluid dynamics analysis. J Biomech Eng, 137(3):031004. https://dx.doi.org/10.1115%2F1.4029017 (IF=2.057)

10. Arciero J, Ellwein L, Ford Versypt AN, Makrides E, Layton AT. (2014) Modeling blood flow control in the kidney. In: Jackson T, Radunskaya A (Eds) Applications of Dynamical Systems in Biology and Medicine (Vol 158, pp.55-73). The IMA Volumes in Mathematics and its Applications. Springer New York. https://doi.org/10.1007/978-1-4939-2782-1_3

9. Ellwein LM, LaDisa JF, Jr., Leibham S, Schindler-Ivens S, Samyn M. (2013) Quantification of thoracic aorta blood flow by magnetic resonance imaging during supine cycling exercise of increasing intensity. J Cardiov Magn Reson, 15 (Suppl 1):P239.  https://doi.org/10.1186/1532-429X-15-S1-P239  (IF=5.601)

8. Ellwein LM, Pope S, Xie A, Batzel JJ, Kelley CT, Olufsen MS. (2013) Patient-specific modeling of cardiovascular and respiratory dynamics during hypercapnia. Math Biosci, 241:56-74. https://dx.doi.org/10.1016%2Fj.mbs.2012.09.003 (IF=1.246)

7. Wendell DC, Samyn MM, Cava JR, Ellwein LM, Krolikowski MM, Gandy KL, Pelech AN, Shadden SC, LaDisa JF. (2013) Including aortic valve morphology in computational fluid dynamics simulations: initial findings and application to aortic coarctation. Med Eng Phys, 35(6):723-735. https://dx.doi.org/10.1016%2Fj.medengphy.2012.07.015 (IF=1.819)

6. Batzel JJ, Ellwein LM, Olufsen MS. (2011) Modeling cardio-respiratory system response to inhaled CO2 in patients with congestive heart failure. Proc 33rd Ann Inter Conf IEEE/EMBC, Boston: 2418-2421.
https://doi.org/10.1109/IEMBS.2011.6090673

5. Ellwein LM, Otake H, Gundert TJ, Koo B-K, Shinke T, Honda Y, Shite J, Ladisa JF, Jr. (2011) Optical coherence tomography for patient-specific 3D artery reconstruction and evaluation of wall shear stress in a left circumflex coronary artery. Cardiovasc Eng Technol, 2(3): 212-227. https://doi.org/10.1007/s13239-011-0047-5 (IF=1.064)

4. LaDisa JF, Jr., Figueroa CA, Vignon-Clementel IE, Kim HJ, Xiao N, Ellwein LM, Chan FP, Feinstein JA, Taylor CA. (2011) Computational simulations for aortic coarctation: representative results from a sampling of patients. J Biomech Eng. 133(9):091008. http://dx.doi.org/10.1115/1.4004996 (IF=2.057)

3. Pope SR, Ellwein LM, Zapata CL, Novak V, Kelley CT, Olufsen MS. (2009) Estimation and identification of parameters in a lumped cerebrovascular model. Math Biosci Eng, 6(1):93-115. http://dx.doi.org/10.3934/mbe.2009.6.93 (IF=1.035)

2. Ellwein LM, Tran H, Zapata CL, Novak V, Olufsen MS. (2008) Sensitivity analysis and model assessment: mathematical models for arterial blood flow and blood pressure. J Cardio Eng, 8(2):94-108. https://doi.org/10.1007/s10558-007-9047-3  (IF= 2.5 (RG))

1. Olufsen MS, Ottesen JT, Tran HT, Ellwein LM, Lipsitz LA, Novak V. (2005) Blood pressure and blood flow variation during postural change from sitting to standing – modeling and experimental validation. J Appl Physiol, 99(4):1523-1537. https://dx.doi.org/10.1152%2Fjapplphysiol.00177.2005  (IF=3.351)

Manuscripts in Preparation

20. Aleiou A, Otake H, Hughey JK, Arzani A,  Ellwein Fix L, LaDisa JF, Jr. Association between post-stenting patient-specific wall shear stress indices and precursors of restenosis or late stent thrombosis after drug-eluting stent implantation. (Manuscript in preparation)

21. Filippas A, Segal R, Ellwein Fix L, Karles T. (2022) Interdisciplinary collaboration to improve knowledge transfer between mathematics and engineering. (Manuscript in preparation)

22. Ellwein Fix L. Parameter identifiability of a respiratory mechanics model in an idealized preterm infant.  http://arxiv.org/abs/1808.00998