[{"id":644,"date":"2024-11-14T16:10:01","date_gmt":"2024-11-14T16:10:01","guid":{"rendered":"https:\/\/blogs.vcu.edu\/mhindle\/?p=644"},"modified":"2024-11-27T20:31:25","modified_gmt":"2024-11-27T20:31:25","slug":"november-2024","status":"publish","type":"post","link":"https:\/\/blogs.vcu.edu\/mhindle\/2024\/11\/14\/november-2024\/","title":{"rendered":"November 2024"},"content":{"rendered":"\n<figure class=\"wp-block-video\"><video height=\"1080\" style=\"aspect-ratio: 1920 \/ 1080;\" width=\"1920\" controls src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Trimmed-Video.mp4\"><\/video><\/figure>\n\n\n\n<p>The last 6 months have been busy and very productive as we continue the development of a dry powder aerosol product for the treatment of neonates with respiratory distress syndrome.<\/p>\n\n\n\n<p>The full video link below shows how we are able to load and deliver 30 mg of formulation in ~ 1 minute using our hand actuator driven dry powder inhaler.  We can aerosolize 30mg of surfactant dry powder formulation using 4 actuations of 10 ml volume at a flow rate of 3 L\/min, suitable for direct administration to neonates.<\/p>\n\n\n\n<p><a href=\"https:\/\/sites.google.com\/vcu.edu\/longest-lab\/videos\/infant-variable-chamber-device?authuser=0\">VCU Surfactant Dry Powder Aerosol Delivery<\/a><\/p>\n\n\n\n<p>Our first two papers describing the formulation development and initial proof of concept in vivo studies have been published in Pharmaceutical Research and are available here:<\/p>\n\n\n\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11095-024-03740-z\">https:\/\/link.springer.com\/article\/10.1007\/s11095-024-03740-z<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11095-024-03754-7\">https:\/\/link.springer.com\/article\/10.1007\/s11095-024-03754-7<\/a><\/p>\n\n\n\n<p>Our PharmD students and post docs presented their work at the VCU School of Pharmacy Research Day and congratulations to Caleb Dalton who was joint winner of the Best Post Doc Poster Award. Anh Truong, Belinda Vu and Sara Arnaout presented their elective and summer research fellowship posters at the meeting. Their work has provided new insights into the effects of relative humidity on our powder formulations. Our PharmD students are also presenting their research at national meetings, Jheanelle Atkinson presented her poster at the Student National Pharmacy Association (SNPHA)\/National Pharmacy Association (NPhA) National Convention in Los Angeles, CA this summer. And Sara Arnaout will present her poster at the ASHP Midyear 2024 Conference in New Orleans, LA in December.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"768\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/FedericaCarnamucioCalebDalton-1-1024x768.jpg\" alt=\"\" class=\"wp-image-653 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/FedericaCarnamucioCalebDalton-1-1024x768.jpg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/FedericaCarnamucioCalebDalton-1-300x225.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/FedericaCarnamucioCalebDalton-1-768x576.jpg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/FedericaCarnamucioCalebDalton-1-1536x1152.jpg 1536w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/FedericaCarnamucioCalebDalton-1-2048x1536.jpg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/768;\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7567-1024x683.jpg\" alt=\"\" class=\"wp-image-652 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7567-1024x683.jpg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7567-300x200.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7567-768x512.jpg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7567-1536x1024.jpg 1536w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7567-2048x1365.jpg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7553-1024x683.jpg\" alt=\"\" class=\"wp-image-648 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7553-1024x683.jpg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7553-300x200.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7553-768x512.jpg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7553-1536x1024.jpg 1536w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_7553-2048x1365.jpg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"698\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/image0-1-1024x698.jpeg\" alt=\"\" class=\"wp-image-667 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/image0-1-1024x698.jpeg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/image0-1-300x204.jpeg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/image0-1-768x523.jpeg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/image0-1-1536x1047.jpeg 1536w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/image0-1-2048x1396.jpeg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/698;\" \/><\/figure>\n\n\n\n<p>It has also been a busy season for conferences with the group attending RDD 2024 in Tucson, AZ, Exploring the Future of Inhalation Drug Delivery, Parma, Italy, AAPS PharmSci360, Salt Lake City, Utah, RDD Asia, Kerala, India and DDL 2024, Edinburgh, Scotland. <\/p>\n\n\n\n<p>RDD 2024 was a great meeting where we presented our latest work and hosted a dinner for current and former VCU students and postdocs. The Exploring the Future of Inhalation Drug Delivery conference had an outstanding programme and was perfectly organized by Dr. Francesca Buttini and her team. The AAPS PharmSci 360 annual meeting continues to be a great forum to reach beyond the inhalation world and catch up on the latest pharmaceutical science. Mohammad Momin&#8217;s poster was selected for one of the Best Abstract Awards and also took part in a presentation in the Special Poster Collection Selection. Mohammad will also be presenting later in the month at RDD Asia, where he will give a podium presentatio on our small animal DPI. Finally, Dr. Hindle is looking forward to attending DDL 2024 in Edinburgh where he was invited to give the DDL Annual Lecture. <\/p>\n\n\n\n<p><strong>RDD 2024<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"487\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8254-1024x487.jpeg\" alt=\"\" class=\"wp-image-658 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8254-1024x487.jpeg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8254-300x143.jpeg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8254-768x366.jpeg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8254-1536x731.jpeg 1536w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8254-2048x975.jpeg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/487;\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"736\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Susan-Sneha-Mike-1024x736.jpg\" alt=\"\" class=\"wp-image-656 lazyload\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/736;width:842px;height:auto\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Susan-Sneha-Mike-1024x736.jpg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Susan-Sneha-Mike-300x216.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Susan-Sneha-Mike-768x552.jpg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Susan-Sneha-Mike-1536x1105.jpg 1536w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Susan-Sneha-Mike-2048x1473.jpg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/figure>\n\n\n\n<p>VCU and Kindeva were delighted to recognize the RDD 2024 Charles G. Thiel Award winner, John Patton. In the words of his nominators: John&#8217;s knowledge and experience are imparted in the gentlest of ways, but despite his standing in the field, he is always willing to learn new things. John is a heck of person to boot!<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"800\" height=\"533\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1715081430817.jpg\" alt=\"\" class=\"wp-image-661 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1715081430817.jpg 800w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1715081430817-300x200.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1715081430817-768x512.jpg 768w\" data-sizes=\"(max-width: 800px) 100vw, 800px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 800px; --smush-placeholder-aspect-ratio: 800\/533;\" \/><\/figure>\n\n\n\n<p>The 2024 VCU RDD Peter R. Byron Graduate Student Award was presented by Dr. Peter Byron to Kinnari Arte, a PhD student at Purdue University, for her poster submission entitled \u201cImpact of L-leucine on Stability and Aerosol Performance of Dry Powder Protein Formulations&#8221;.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"938\" height=\"591\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Kinnari1.jpg\" alt=\"\" class=\"wp-image-663 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Kinnari1.jpg 938w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Kinnari1-300x189.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/Kinnari1-768x484.jpg 768w\" data-sizes=\"(max-width: 938px) 100vw, 938px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 938px; --smush-placeholder-aspect-ratio: 938\/591;\" \/><\/figure>\n\n\n\n<p><strong>Parma 2024<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1726050048444-1024x683.jpg\" alt=\"\" class=\"wp-image-662 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1726050048444-1024x683.jpg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1726050048444-300x200.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1726050048444-768x512.jpg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1726050048444-1536x1024.jpg 1536w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1726050048444.jpg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/683;\" \/><\/figure>\n\n\n\n<p><strong>AAPS 2024<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"716\" height=\"498\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1729516610311-1.jpg\" alt=\"\" class=\"wp-image-668 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1729516610311-1.jpg 716w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1729516610311-1-300x209.jpg 300w\" data-sizes=\"(max-width: 716px) 100vw, 716px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 716px; --smush-placeholder-aspect-ratio: 716\/498;\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"646\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1729700897405-1-1024x646.jpg\" alt=\"\" class=\"wp-image-664 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1729700897405-1-1024x646.jpg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1729700897405-1-300x189.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1729700897405-1-768x484.jpg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1729700897405-1-1536x968.jpg 1536w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/1729700897405-1.jpg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/646;\" \/><\/figure>\n\n\n\n<p>Finally, it was very special to receive hand drawn thank you cards with all our favourite inhalers and lab equipment. We have an artist amoung us (Anh !). <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"768\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8592-1024x768.jpg\" alt=\"\" class=\"wp-image-669 lazyload\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8592-1024x768.jpg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8592-300x225.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8592-768x576.jpg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8592-1536x1152.jpg 1536w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/11\/IMG_8592-2048x1536.jpg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/768;\" \/><\/figure>\n\n\n\n<p>Our progress over the last year is mindblowing, our VCUPharmacy and VCUEngineering team are well on the way to developing a powder aerosol treatment of infants with RDS. We have some great PharmD students working in the lab this year Anh Truong, Sara Arnaout, Jheanelle Atkinson and Belinda Vu. Thanks for everyones hard work.. Mohammad Momin, Dale Farkas, Caleb Dalton, Felicia Hall, Ghali Aladwani, Sarah Strickler, Hasan Jubaer, Arun Varghese Kolanjiyil, Rabijit Dutta, Morgan Thomas, Casey Grey.  All would not be possible without outstanding and giving collaborators, Worth Longest, Laleh Golshahi, Qingguo Xu, Rebecca Heise and Rob DiBlasi.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The last 6 months have been busy and very productive as we continue the development of a dry powder aerosol product for the treatment of neonates with respiratory distress syndrome. The full video link below shows how we are able to load and deliver 30 mg of formulation in ~ 1 minute using our hand [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3],"class_list":["post-644","post","type-post","status-publish","format-standard","hentry","category-news","tag-in-the-news"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/644","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/comments?post=644"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/644\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/media?parent=644"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/categories?post=644"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/tags?post=644"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":636,"date":"2024-02-26T18:44:26","date_gmt":"2024-02-26T18:44:26","guid":{"rendered":"https:\/\/blogs.vcu.edu\/mhindle\/?p=636"},"modified":"2024-02-26T18:51:49","modified_gmt":"2024-02-26T18:51:49","slug":"february-2024","status":"publish","type":"post","link":"https:\/\/blogs.vcu.edu\/mhindle\/2024\/02\/26\/february-2024\/","title":{"rendered":"February 2024"},"content":{"rendered":"\n<p>The last year has been very busy as we progress our development of an inhaled powder surfactant formulation for the treatment of infants with Respiratory Distress Syndrome. <a href=\"https:\/\/news.vcu.edu\/article\/2023\/08\/vcu-researchers-developing-affordable-noninvasive-treatment-for-rds-in-newborns\" data-type=\"link\" data-id=\"https:\/\/news.vcu.edu\/article\/2023\/08\/vcu-researchers-developing-affordable-noninvasive-treatment-for-rds-in-newborns\">Here is a recent VCU news article about this work<\/a>. <img decoding=\"async\" width=\"1800\" height=\"1200\" class=\"wp-image-639 lazyload\" style=\"--smush-placeholder-width: 1800px; --smush-placeholder-aspect-ratio: 1800\/1200;width: 800px\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/230120_005_4x6_aj.jpg\" alt=\"\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/230120_005_4x6_aj.jpg 1800w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/230120_005_4x6_aj-300x200.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/230120_005_4x6_aj-1024x683.jpg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/230120_005_4x6_aj-768x512.jpg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/230120_005_4x6_aj-1536x1024.jpg 1536w\" data-sizes=\"(max-width: 1800px) 100vw, 1800px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/p>\n\n\n\n<p>Our lab has a number of new members, including Dr. Felicia Hall and Dr. Caleb Dalton as Post Doctoral Fellows. Dr. Mohammad Momin was promoted to Research Assistant Professor. Congratulations !!!<\/p>\n\n\n\n<p> <img decoding=\"async\" width=\"1024\" height=\"768\" class=\"wp-image-637 lazyload\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/768;width: 800px\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/IMG_6560.jpg\" alt=\"\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/IMG_6560.jpg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/IMG_6560-300x225.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/IMG_6560-768x576.jpg 768w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/p>\n\n\n\n<p>Jheanelle Atkinson (PharmD Student),  presented her work at our recent VCU School of Pharmacy Research and Career Day. Her poster was entitled &#8220;Investigation of the effect of storage conditions on the physicochemical stability of a synthetic lung surfactant dry powder formulation&#8221;. <\/p>\n\n\n\n<p>We continue to open to lab to give research experiences to VCU students from across the campus. Sara Arnaout, a P3 PharmD student joined the group for a research elective in Spring 2024. And we also welcomed Nadeem Jaheer for a research elective in the Spring 2024 semester, Nadeem is majoring in Biology here at VCU.  <\/p>\n\n\n\n<p>We said good luck to Nicole Sadler who worked in the lab during her time at VCU pursuing her  Chemistry BS and Masters Degrees. Good luck Nicole at Eurofins and thank you !<\/p>\n\n\n\n<p><a href=\"https:\/\/news.vcu.edu\/article\/2023\/01\/national-academy-of-inventors-names-michael-hindle-an-nai-fellow\">Dr. Hindle was elected as a Fellow of the National Academy of Inventors and was inducted at their annual meeting in July 2023<\/a>. <img decoding=\"async\" width=\"2400\" height=\"1600\" class=\"wp-image-638 lazyload\" style=\"--smush-placeholder-width: 2400px; --smush-placeholder-aspect-ratio: 2400\/1600;width: 800px\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/53024559962_31156c9fd1_o.jpg\" alt=\"\" data-srcset=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/53024559962_31156c9fd1_o.jpg 2400w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/53024559962_31156c9fd1_o-300x200.jpg 300w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/53024559962_31156c9fd1_o-1024x683.jpg 1024w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/53024559962_31156c9fd1_o-768x512.jpg 768w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/53024559962_31156c9fd1_o-1536x1024.jpg 1536w, https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2024\/02\/53024559962_31156c9fd1_o-2048x1365.jpg 2048w\" data-sizes=\"(max-width: 2400px) 100vw, 2400px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><\/p>\n\n\n\n<p>Our latest publications include:<\/p>\n\n\n\n<p>Development of an effective two-equation turbulence modeling approach for simulating aerosol deposition across a range of turbulence levels. H Jubaer, M Thomas, D Farkas, AV Kolanjiyil, MAM Momin, M Hindle, \u2026 Journal of Aerosol Science 175, 106262 1 2024<br><br>Advancement of a high-dose infant air-jet dry powder inhaler (DPI) with passive cyclic loading: Performance tuning for different formulations. C Howe, MAM Momin, G Aladwani, S Strickler, M Hindle, W Longest. International Journal of Pharmaceutics 643, 123199 2023<br><br>Effects of Different Mesh Nebulizer Sources on the Dispersion of Powder Formulations Produced with a New Small-Particle Spray Dryer. G Aladwani, MAM Momin, B Spence, DR Farkas, S Bonasera, A Hassan, \u2026<br>International Journal of Pharmaceutics, 123138 2023<br><br>Near Elimination of In Vitro Predicted Extrathoracic Aerosol Deposition in Children Using a Spray-Dried Antibiotic Formulation and Pediatric Air-Jet DPI. D Farkas, ML Thomas, A Hassan, S Bonasera, M Hindle, W Longest. Pharmaceutical Research 40 (5), 1193-1207 3 2023<\/p>\n\n\n\n<p>Establishing quantitative relationships between changes in nasal spray in vitro metrics and drug delivery to the posterior nasal region. AV Kolanjiyil, R Walenga, A Babiskin, L Golshahi, M Hindle, W Longest. <br>International Journal of Pharmaceutics 635, 122718 3 2023.<\/p>\n\n\n\n<p>New Air-Jet Dry Powder Insufflator for High-Efficiency Aerosol Delivery to Rats. R Pangeni, AAM Hassan, D Farkas, H Sudarjat, W Longest, M Hindle, \u2026 Molecular Pharmaceutics 20 (4), 2207-2216 1 2023<\/p>\n\n\n\n<p>Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers. R Pangeni, T Meng, S Poudel, D Sharma, H Hutsell, J Ma, BK Rubin, \u2026<br>International Journal of Pharmaceutics, 122661 19 2023<\/p>\n\n\n\n<p>Effects of nasal anatomical characteristics and administration parameters on delivery of locally-acting drugs with suspension nasal sprays in adults S Hosseini, A Alfaifi, AR Esmaeili, D Edwards, T Schuman, W Longest, \u2026Journal of Aerosol Science 167, 106101<\/p>\n\n\n\n<p><strong>Finally, we received a US Patent for one of our key inhaler device patents. US Patent # 11,690,964,  Devices, systems, and methods for dry powder therapies was issued 7\/4\/2023. Congratulations to inventors, Worth Longest, Dale Farkas, Susan Boc and Mike Hindle.  <\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The last year has been very busy as we progress our development of an inhaled powder surfactant formulation for the treatment of infants with Respiratory Distress Syndrome. Here is a recent VCU news article about this work. Our lab has a number of new members, including Dr. Felicia Hall and Dr. Caleb Dalton as Post [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3],"class_list":["post-636","post","type-post","status-publish","format-standard","hentry","category-news","tag-in-the-news"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/636","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/comments?post=636"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/636\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/media?parent=636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/categories?post=636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/tags?post=636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":622,"date":"2022-08-31T16:33:48","date_gmt":"2022-08-31T16:33:48","guid":{"rendered":"https:\/\/blogs.vcu.edu\/mhindle\/?p=622"},"modified":"2022-09-22T17:15:53","modified_gmt":"2022-09-22T17:15:53","slug":"summer-2022","status":"publish","type":"post","link":"https:\/\/blogs.vcu.edu\/mhindle\/2022\/08\/31\/summer-2022\/","title":{"rendered":"Summer 2022"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img decoding=\"async\" width=\"808\" height=\"1080\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2022\/08\/Rabbit-Aerosol-2-2.png\" alt=\"\" class=\"wp-image-626 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 808px; --smush-placeholder-aspect-ratio: 808\/1080;\" \/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>We are continuing to work on a series of projects delivering aerosols to challenging patient populations including developing a powder lung surfactant product for administration as aerosol. The image shows a surfactant powder aerosol being delivered through a model of the rabbit upper tracheobronchial airways.  This aerosol was dispersed with only 15 ml of air at a flow rate of 6L\/min using our novel air-jet dry powder inhaler technology. <\/p>\n\n\n\n<p>Our intellectual property portfolio continues to expand with a patent granted for our nebulizer mixer heater technology that improves the efficiency of conventional nebulizers by reducing the aerosol droplet size.  Congratulations to our co-inventors: Worth Longest, Michael Hindle, Ben Spence, Sneha Dhapare, Xiangyin Wei. <\/p>\n\n\n\n<p>Patent title: Combination devices, systems, and methods for humidification of the airways and high efficiency delivery of pharmaceutical aerosols<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2022\/08\/US20200139074A1-20200507-D00005.png\" alt=\"\" class=\"wp-image-632 lazyload\" width=\"715\" height=\"783\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 715px; --smush-placeholder-aspect-ratio: 715\/783;\" \/><\/figure>\n\n\n\n<p>The RDD 2022 meeting in Spring was a great success, with our group contributing to 8 poster and 2 podium presentations and the first time we had all gathered as a group since the beginning of the pandemic.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"800\" height=\"600\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2022\/08\/VCU@RDD2022.jpeg\" alt=\"\" class=\"wp-image-631 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 800px; --smush-placeholder-aspect-ratio: 800\/600;\" \/><\/figure>\n\n\n\n<p>Esmaeili AR, Hosseini, Wilkins J, Alfaifi A, Dhapare S, Walenga R, Newman B, Schuman T, Longest PW, Hindle M, Golshahi L: \u201cIn Vitro Evaluation of Regional Drug Deposition in Nasal Airways of Children Using Realistic Anatomical Replicas\u201d <\/p>\n\n\n\n<p>Farkas DR, Bonasera, Thomas ML, Hassan A, Hindle M, Longest PW: \u201cIn Vitro Evaluation of Dry Powder Aerosol Delivery Efficiency to the Lungs of Preterm Infants Using Two Administration Approaches\u201d<\/p>\n\n\n\n<p>Farkas DR, Hindle M, Longest PW: \u201cIn Vitro Performance of a Pediatric Air-Jet DPI Delivering a Spray-Dried Antibiotic Formulation\u201d<\/p>\n\n\n\n<p>Momin MAM, Farkas DR, Longest PW, Hindle M: \u201cLong-term Storage Stability of an Excipient Enhanced Growth (EEG) Pulmonary Surfactant Powder Formulation\u201d<\/p>\n\n\n\n<p>Momin MAM, Howe C, Longest PW, Hindle M: \u201cSurfactant Powder Delivery from Infant Air-Jet Dry Powder Inhaler (DPI): Effect of Flow Rate and DPI Design\u201d<\/p>\n\n\n\n<p>Xu Q, Hassan A, Meng T, Pangeni R, Rubin BK, Longest PW, Hindle: \u201dDry Powder Aerosol Containing Muco-Inert Particles for Pulmonary Drug Delivery\u201d<\/p>\n\n\n\n<p>Pangeni R, Hassan A, Loch K, Sudarjat H, Meng T, Momin MAM, Longest PW, Hindle M, Xu Q: \u201cLiposomal Dry Powder Aerosol Formulation of Ciprofloxacin: Effect of Sucrose and Mannitol on Aerosol Performance\u201d<\/p>\n\n\n\n<p>Bonasera S, Farkas DR, Hassan A, Longest PW, Hindle M: \u201cOptimization and Characterization of a Tobramycin Excipient Enhanced Growth Spray-Dried Powder Formulation\u201d<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We are continuing to work on a series of projects delivering aerosols to challenging patient populations including developing a powder lung surfactant product for administration as aerosol. The image shows a surfactant powder aerosol being delivered through a model of the rabbit upper tracheobronchial airways. This aerosol was dispersed with only 15 ml of air [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3],"class_list":["post-622","post","type-post","status-publish","format-standard","hentry","category-news","tag-in-the-news"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/622","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/comments?post=622"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/622\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/media?parent=622"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/categories?post=622"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/tags?post=622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":557,"date":"2021-10-28T16:25:33","date_gmt":"2021-10-28T16:25:33","guid":{"rendered":"https:\/\/blogs.vcu.edu\/mhindle\/?p=557"},"modified":"2021-10-28T16:42:24","modified_gmt":"2021-10-28T16:42:24","slug":"fall-2021","status":"publish","type":"post","link":"https:\/\/blogs.vcu.edu\/mhindle\/2021\/10\/28\/fall-2021\/","title":{"rendered":"Fall 2021"},"content":{"rendered":"\n<p>Congratulations to Serena Bonasera, Ph.D., its official. Google Scholar listed her dissertation. Despite a pandemic shutting down the lab, she successfully completed her research project and defended her dissertation recently. Serena has been an invaluable lab member of the last 4 years. Always enthusiastic to learn and become the best scientist possible. Thanks for all your help, Serena, and good luck.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"800\" height=\"164\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2021\/10\/1635186664083.jpg\" alt=\"\" class=\"wp-image-560 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 800px; --smush-placeholder-aspect-ratio: 800\/164;\" \/><\/figure>\n\n\n\n<p>As Serena leaves the lab, we are pleased to welcome Dr. Sarah Aboelela to the Aerosol Research Group. Sarah has recently graduated from Dr. Tom Ropers lab in the College of Engineering at VCU. She brings a wide range of pharmaceutical manufacturing expertise to the group.<\/p>\n\n\n\n<p>Our research project continue to expand with new projects and collaborations with the Bill and Melinda Gates Foundation and a collaborative project with the US FDA awarded to Dr. <a href=\"https:\/\/sites.google.com\/vcu.edu\/longest-lab\/home\" target=\"_blank\" rel=\"noreferrer noopener\">Worth Longest<\/a>&#8216;s group. This 2nd <a rel=\"noreferrer noopener\" href=\"https:\/\/www.gatesfoundation.org\/about\/committed-grants\/2021\/03\/inv029019\" target=\"_blank\">Gates Foundation grant<\/a> has allowed the lab to expand its dry powder formulation stability study capabilities with the purchase of bench top blister packaging machine for capsules, together with new stability ovens and a state of the art bubble pressure tensiometer. We will be focusing on the development of surfactant formulations and devices for delivery to neonates in  low resource settings. This new <a rel=\"noreferrer noopener\" href=\"https:\/\/reporter.nih.gov\/search\/nid0XFNmekijJGj8F1wugw\/project-details\/10372282\" data-type=\"URL\" data-id=\"https:\/\/reporter.nih.gov\/search\/nid0XFNmekijJGj8F1wugw\/project-details\/10372282\" target=\"_blank\">FDA U01<\/a> is focused on the development of CFD models to aid the development of generic metered dose inhalers.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"4032\" height=\"3024\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2021\/10\/IMG-4335.jpg\" alt=\"\" class=\"wp-image-559 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 4032px; --smush-placeholder-aspect-ratio: 4032\/3024;\" \/><\/figure>\n\n\n\n<p>Our students and post docs continue to publish high impact papers including :<\/p>\n\n\n\n<p><a href=\"https:\/\/scholar.google.com\/citations?view_op=view_citation&amp;hl=en&amp;user=pzPKFD8AAAAJ&amp;sortby=pubdate&amp;citation_for_view=pzPKFD8AAAAJ:KxdiYzj_eL0C\">Performance of Low Air Volume Dry Powder Inhalers (LV-DPI) when Aerosolizing Excipient Enhanced Growth (EEG) Surfactant Powder Formulations<\/a> S Boc, MAM Momin, DR Farkas, W Longest, M Hindle. AAPS PharmSciTech 22 (4), 1-12<\/p>\n\n\n\n<p><a href=\"https:\/\/scholar.google.com\/citations?view_op=view_citation&amp;hl=en&amp;user=pzPKFD8AAAAJ&amp;sortby=pubdate&amp;citation_for_view=pzPKFD8AAAAJ:Xtec1x7NZGAC\">Development and Characterization of Excipient Enhanced Growth (EEG) Surfactant Powder Formulations for Treating Neonatal Respiratory Distress Syndrome<\/a> S Boc, MAM Momin, DR Farkas, W Longest, M Hindle. AAPS PharmSciTech 22 (4), 1-12<\/p>\n\n\n\n<p><a href=\"https:\/\/scholar.google.com\/citations?view_op=view_citation&amp;hl=en&amp;user=pzPKFD8AAAAJ&amp;sortby=pubdate&amp;citation_for_view=pzPKFD8AAAAJ:1W67FsDfIBAC\">Advancement of the Infant Air-Jet Dry Powder Inhaler (DPI): Evaluation of Different Positive-Pressure Air Sources and Flow Rates<\/a> C Howe, MAM Momin, DR Farkas, S Bonasera, M Hindle, P Longest. Pharmaceutical Research 38 (9), 1615-1632<\/p>\n\n\n\n<p>We are looking forward to resuming conference presentations in 2022, with <a href=\"https:\/\/www.rddonline.com\/rdd\/rdd.php?id=21&amp;sid=1\" data-type=\"URL\" data-id=\"https:\/\/www.rddonline.com\/rdd\/rdd.php?id=21&amp;sid=1\">RDD 2022<\/a> in Orlando being the highlight for next year. <\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congratulations to Serena Bonasera, Ph.D., its official. Google Scholar listed her dissertation. Despite a pandemic shutting down the lab, she successfully completed her research project and defended her dissertation recently. Serena has been an invaluable lab member of the last 4 years. Always enthusiastic to learn and become the best scientist possible. Thanks for all [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-557","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/comments?post=557"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/557\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/media?parent=557"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/categories?post=557"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/tags?post=557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":542,"date":"2021-02-16T19:16:32","date_gmt":"2021-02-16T19:16:32","guid":{"rendered":"https:\/\/blogs.vcu.edu\/mhindle\/?p=542"},"modified":"2021-03-04T17:01:27","modified_gmt":"2021-03-04T17:01:27","slug":"2021-new-year-update","status":"publish","type":"post","link":"https:\/\/blogs.vcu.edu\/mhindle\/2021\/02\/16\/2021-new-year-update\/","title":{"rendered":"2021 New Year Update"},"content":{"rendered":"\n<p>2020 was challenging for all the obvious reasons, but we were able to return to work in July after our mandatory work from home period. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"2320\" height=\"3088\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2021\/02\/class.jpg\" alt=\"\" class=\"wp-image-546 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 2320px; --smush-placeholder-aspect-ratio: 2320\/3088;\" \/><\/figure>\n\n\n\n<p>Everyone in the lab has faced challenges over the past year, educating children from home, not being able to travel home to visit family and just dealing with the pandemic. Our annual lab celebration took place with pizza on a bench outside the Smith Building while we socially distanced. And I taught in empty classrooms. <\/p>\n\n\n\n<p>But we have persisted and I am forever grateful for everyone&#8217;s support, enthusiasm and hard work in the last 12 months. Thank you, Amr, Mohammad, Serena, Nicole, Kelsey and Timothy, together with Dr. Longest&#8217;s team in Engineering and all our collaborators in the Golshahi, Xu and Heise labs.<\/p>\n\n\n\n<p>Our projects continue to expand working on a <a href=\"https:\/\/egr.vcu.edu\/news-events\/news\/02012021-golshahi-16-million-fda-contract.html#\" target=\"_blank\" rel=\"noreferrer noopener\">new FDA contract with Drs. Golshahi and Longest <\/a>together with <a href=\"https:\/\/egr.vcu.edu\/news-events\/news\/12092020-worth-longest-gates-foundation-grant-for-infant-respirators.html#\" target=\"_blank\" rel=\"noreferrer noopener\">an investment from the Bill and Melinda Gates Foundation<\/a><\/p>\n\n\n\n<p>As we expand our research, we also continue to update our equipment, we now have a state of the art rheometer to characterize powder flow, the <a rel=\"noreferrer noopener\" href=\"https:\/\/www.freemantech.co.uk\/powder-testing\/ft4-powder-rheometer-powder-flow-tester\" target=\"_blank\">FT4 from Freeman Technologies. <\/a>Last week, we installed our new powder x-ray diffractometer, the <a rel=\"noreferrer noopener\" href=\"https:\/\/www.rigaku.com\/products\/xrd\/miniflex\" target=\"_blank\">Rigaku Miniflex 600<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"4032\" height=\"3024\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2021\/02\/Miniflex.jpg\" alt=\"\" class=\"wp-image-544 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 4032px; --smush-placeholder-aspect-ratio: 4032\/3024;\" \/><\/figure>\n\n\n\n<p>Our publications continue to cover the scope of our research on powder formulation, device development, computational modeling and regulatory research.<\/p>\n\n\n\n<p>In vitro evaluation of regional nasal drug delivery using multiple anatomical nasal replicas of adult human subjects and two nasal sprays.<br>Manniello MD, Hosseini S, Alfaifi A, Esmaeili AR, Kolanjiyil AV, Walenga R, Babiskin A, Sandell D, Mohammadi R, Schuman T, Hindle M, Golshahi L.<br>Int J Pharm. 2021 Jan 25;593:120103. doi: 10.1016\/j.ijpharm.2020.120103. Epub 2020 Nov 23.<\/p>\n\n\n\n<p>Characterization of excipient enhanced growth (EEG) tobramycin dry powder aerosol formulations.<br>Hassan A, Farkas D, Longest W, Hindle M.<br>Int J Pharm. 2020 Dec 15;591:120027. doi: 10.1016\/j.ijpharm.2020.120027. Epub 2020 Oct 31.<\/p>\n\n\n\n<p>CFD Guided Optimization of Nose-to-Lung Aerosol Delivery in Adults: Effects of Inhalation Waveforms and Synchronized Aerosol Delivery.<br>Dutta R, Spence B, Wei X, Dhapare S, Hindle M, Longest PW.<br>Pharm Res. 2020 Sep 24;37(10):199. doi: 10.1007\/s11095-020-02923-8.<\/p>\n\n\n\n<p>Advancement of a Positive-Pressure Dry Powder Inhaler for Children: Use of a Vertical Aerosolization Chamber and Three-Dimensional Rod Array Interface.<br>Farkas D, Bonasera S, Bass K, Hindle M, Longest PW.<br>Pharm Res. 2020 Aug 30;37(9):177. doi: 10.1007\/s11095-020-02889-7.<\/p>\n\n\n\n<p>Initial Development of an Air-Jet Dry Powder Inhaler for Rapid Delivery of Pharmaceutical Aerosols to Infants.<br>Howe C, Hindle M, Bonasera S, Rani V, Longest PW.<br>J Aerosol Med Pulm Drug Deliv. 2021 Feb;34(1):57-70. doi: 10.1089\/jamp.2020.1604. Epub 2020 Aug 4.<\/p>\n\n\n\n<p>Dry powder aerosol containing muco-inert particles for excipient enhanced growth pulmonary drug delivery.<br>Chai G, Hassan A, Meng T, Lou L, Ma J, Simmers R, Zhou L, Rubin BK, Zhou QT, Longest PW, Hindle M, Xu Q.<br>Nanomedicine. 2020 Oct;29:102262. doi: 10.1016\/j.nano.2020.102262. Epub 2020 Jul 3.<\/p>\n\n\n\n<p>Excipient Enhanced Growth Aerosol Surfactant Replacement Therapy in an In Vivo Rat Lung Injury Model.<br>Kamga Gninzeko FJ, Valentine MS, Tho CK, Chindal SR, Boc S, Dhapare S, Momin MAM, Hassan A, Hindle M, Farkas DR, Longest PW, Heise RL.<br>J Aerosol Med Pulm Drug Deliv. 2020 Dec;33(6):314-322. doi: 10.1089\/jamp.2020.1593. Epub 2020 May 21.<\/p>\n\n\n\n<p>Computational Fluid Dynamics (CFD) Simulations of Spray Drying: Linking Drying Parameters with Experimental Aerosolization Performance.<br>Longest PW, Farkas D, Hassan A, Hindle M.<br>Pharm Res. 2020 May 21;37(6):101. doi: 10.1007\/s11095-020-02806-y.<br><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2020 was challenging for all the obvious reasons, but we were able to return to work in July after our mandatory work from home period. Everyone in the lab has faced challenges over the past year, educating children from home, not being able to travel home to visit family and just dealing with the pandemic. [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3],"class_list":["post-542","post","type-post","status-publish","format-standard","hentry","category-news","tag-in-the-news"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/comments?post=542"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/542\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/media?parent=542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/categories?post=542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/tags?post=542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":525,"date":"2020-04-27T10:46:43","date_gmt":"2020-04-27T10:46:43","guid":{"rendered":"https:\/\/blogs.vcu.edu\/mhindle\/?p=525"},"modified":"2020-04-27T10:59:08","modified_gmt":"2020-04-27T10:59:08","slug":"digital-rdd-2020","status":"publish","type":"post","link":"https:\/\/blogs.vcu.edu\/mhindle\/2020\/04\/27\/digital-rdd-2020\/","title":{"rendered":"Digital RDD 2020"},"content":{"rendered":"\n<p>Congratulations to Jeff Weers as the 2020 recipient of the Thiel Award #DigitalRDD2020. Well deserved !<\/p>\n\n\n\n<p>I am very proud of our #VCUPharmacy and #VCUEngineering students and post docs who have prepared 17 poster presentations for this years virtual RDD meeting. I know these last months have been difficult for everyone but your hard work and dedication does not go unnoticed and these presentations are something you all should be proud of. Please register for #DigitalRDD2020 and check out their work. <\/p>\n\n\n\n<p><a href=\"https:\/\/www.rddonline.com\">https:\/\/www.rddonline.com<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Congratulations to Jeff Weers as the 2020 recipient of the Thiel Award #DigitalRDD2020. Well deserved ! I am very proud of our #VCUPharmacy and #VCUEngineering students and post docs who have prepared 17 poster presentations for this years virtual RDD meeting. I know these last months have been difficult for everyone but your hard work [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-525","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/525","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/comments?post=525"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/525\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/media?parent=525"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/categories?post=525"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/tags?post=525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":518,"date":"2019-10-25T14:43:48","date_gmt":"2019-10-25T14:43:48","guid":{"rendered":"https:\/\/blogs.vcu.edu\/mhindle\/?p=518"},"modified":"2019-10-25T14:43:49","modified_gmt":"2019-10-25T14:43:49","slug":"fall-2019-update","status":"publish","type":"post","link":"https:\/\/blogs.vcu.edu\/mhindle\/2019\/10\/25\/fall-2019-update\/","title":{"rendered":"Fall 2019 Update"},"content":{"rendered":"\n<p>Our group will be attending the 2019 AAPS Annual Meeting. Check out the following posters<\/p>\n\n\n\n<p>M0930-01-02 &#8211; Investigation of Pharmacokinetic Sensitivity to Regional Lung Deposition of Locally-Acting Orally Inhaled Drug Products &#8211;&nbsp;Mon, Nov -9:30 AM \u2013 10:30 AM<\/p>\n\n\n\n<p>M0930-01-03 &#8211; Evaluating the Batch to Batch Reproducibility and Aerosol Performance of Spray Dried Albuterol Sulfate Formulations Using Cascade Impaction and Laser Diffraction Methods &#8211;&nbsp;Mon, Nov 4 &#8211;&nbsp;9:30 AM \u2013 10:30 AM<\/p>\n\n\n\n<p>M1130-07-48 &#8211; In Vitro Investigation of Regional Nasal Drug Delivery using Two Glucocorticoid Nasal Spray Products and Twenty Anatomical Nasal Replicas &#8211;&nbsp;Mon, Nov 4 &#8211; 11:30 AM \u2013 12:30 PM<\/p>\n\n\n\n<p>T0930-01-01 &#8211; Preparation, Characterization, and Aerosol Performance Testing of Engineered Spray Dried Tobramycin Dry Powder Aerosol Formulation &#8211; Tue, Nov 5 &#8211; 9:30 AM \u2013 10:30 AM<\/p>\n\n\n\n<p>Also read about our NIH funded research developing formulations and inhalers for infants and children.<\/p>\n\n\n\n<p><a href=\"https:\/\/egr.vcu.edu\/news-events\/news\/engineering-and-pharmacy-make-inhaled-medications-more-effective.html#\">https:\/\/egr.vcu.edu\/news-events\/news\/engineering-and-pharmacy-make-inhaled-medications-more-effective.html#<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our group will be attending the 2019 AAPS Annual Meeting. Check out the following posters M0930-01-02 &#8211; Investigation of Pharmacokinetic Sensitivity to Regional Lung Deposition of Locally-Acting Orally Inhaled Drug Products &#8211;&nbsp;Mon, Nov -9:30 AM \u2013 10:30 AM M0930-01-03 &#8211; Evaluating the Batch to Batch Reproducibility and Aerosol Performance of Spray Dried Albuterol Sulfate Formulations [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3],"class_list":["post-518","post","type-post","status-publish","format-standard","hentry","category-news","tag-in-the-news"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/comments?post=518"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/518\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/media?parent=518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/categories?post=518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/tags?post=518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":515,"date":"2019-10-25T14:39:06","date_gmt":"2019-10-25T14:39:06","guid":{"rendered":"https:\/\/blogs.vcu.edu\/mhindle\/?p=515"},"modified":"2021-11-23T15:40:47","modified_gmt":"2021-11-23T15:40:47","slug":"summer-2019-update-part-2","status":"publish","type":"post","link":"https:\/\/blogs.vcu.edu\/mhindle\/2019\/10\/25\/summer-2019-update-part-2\/","title":{"rendered":"Summer 2019 Update Part 2"},"content":{"rendered":"\n<p>We have also been busy updating the lab with over $300,000 spent on new equipment.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"4032\" height=\"3024\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2021\/11\/IMG-1973.jpg\" alt=\"\" class=\"wp-image-580 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 4032px; --smush-placeholder-aspect-ratio: 4032\/3024;\" \/><\/figure>\n\n\n\n<p>The SMS DVS Adventure &#8211; an advanced water sorption analyzer with Raman probe to investigate the stability and hygroscopicity of our spray dried powders.<\/p>\n\n\n\n<p>The Proveris SprayView is an industry leading technology for the characterization of spray patterns for inhalers and nasal sprays.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"4032\" height=\"3024\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2021\/11\/IMG-1974.jpg\" alt=\"\" class=\"wp-image-581 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 4032px; --smush-placeholder-aspect-ratio: 4032\/3024;\" \/><\/figure>\n\n\n\n<p>We are grateful for the financial support of&nbsp;our emeritus professor, Dr. Peter Byron, and Dr. Doug Sweet, Chair, Department of Pharmaceutics, as we continue&nbsp;our efforts to maintain a state of the art aerosol science laboratory. We look forward to welcoming alumni and visitors to check out our newest acquisitions and tour the labs.<\/p>\n\n\n\n<p>We are continuing to move towards our first clinical studies with our EEG aerosol delivery technology with our safety and tolerability study planned for the Fall. And working with Dr. Rebecca Heise, we have promising data showing our aerosolized EEG dry powder surfactant formulation is more effective than the instilled liquid form. We will be presenting this work at upcoming conferences.<\/p>\n\n\n\n<p>We also recently were granted two patents for our EEG technologies, for both non-invasive ventilation delivery and dry powder inhaler delivery.<\/p>\n\n\n\n<p>Longest PW, Hindle M: \u201cSystems, devices, and methods for changing therapeutic aerosol size and improving efficiency of ventilation and aerosol drug delivery\u201d, US Patent # 10,010692.<\/p>\n\n\n\n<p>Longest PW, Hindle M, Son Y-J, Behara SRB, Farkas D, \u201cDry powder inhaler (DPI) designs for producing aerosols with high fine particle fractions\u201d. US Patent # 10,105500.<\/p>\n\n\n\n<p>Finally, for the summer, thanks to Mukul, Amr and Serena, for organizing a lab cookout at Echo Lake Park, the food was good and the weather hot. And the 3G signal was even sufficient to watch England win the Cricket World Cup !<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We have also been busy updating the lab with over $300,000 spent on new equipment. The SMS DVS Adventure &#8211; an advanced water sorption analyzer with Raman probe to investigate the stability and hygroscopicity of our spray dried powders. The Proveris SprayView is an industry leading technology for the characterization of spray patterns for inhalers [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3],"class_list":["post-515","post","type-post","status-publish","format-standard","hentry","category-news","tag-in-the-news"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/comments?post=515"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/515\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/media?parent=515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/categories?post=515"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/tags?post=515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":513,"date":"2019-10-25T14:38:06","date_gmt":"2019-10-25T14:38:06","guid":{"rendered":"https:\/\/blogs.vcu.edu\/mhindle\/?p=513"},"modified":"2021-11-23T16:18:02","modified_gmt":"2021-11-23T16:18:02","slug":"summer-update-part-1","status":"publish","type":"post","link":"https:\/\/blogs.vcu.edu\/mhindle\/2019\/10\/25\/summer-update-part-1\/","title":{"rendered":"Summer Update Part 1"},"content":{"rendered":"\n<p>Spring and Summer 2019 have been very busy and productive for the lab.<\/p>\n\n\n\n<p>We said good bye, good luck and thanks to Dr. Sneha Dhapare who was recruited to join the US FDA.<\/p>\n\n\n\n<p>In February and March, we welcomed two new Post Docs into the lab. Dr. Mohammad Momin joined from Dr. Shyamal Das&#8217;s lab in New Zealand. Dr. Mukul Kelkar was also welcomed into the group.<\/p>\n\n\n\n<p>We have also been fortunate to have two PharmD students working in the lab during the summer, Timothy Meinhardt and Daniel Booth. Both have been gaining research experience and recently presented their summer work to the School of Pharmacy Summer Research Fellowship program and did a great job.<\/p>\n\n\n\n<p>Serena Bonasera was the recipient of a number of awards recently including&nbsp;the Rector Rorrer travel award and the Schwartz award.&nbsp; She represented the group at the Drug Delivery to the Lungs Conference in Edinburgh, where she presented a poster entitled &#8220;Effect of spray dried formulation on the aerosol performance of a novel dry powder inhaler\u201d.&nbsp;Congratulations Serena.<\/p>\n\n\n\n<p>Amr Hassan presented a poster entitled \u201cRealistic aerosol performance testing of novel budesonide excipient enhanced growth dry powder formulations\u201d, at the&nbsp;American Association of Pharmaceutical Scientists Annual Meeting, Washington DC. This work is performed in collaboration with Quench Medical.&nbsp;Quench Medical are translating the innovations in aerosol drug delivery developed at VCU into therapies. We are continuing our work together and are excited to support Bryce and his team in their development efforts.<\/p>\n\n\n\n<p>Check out our <a href=\"http:\/\/blogs.vcu.edu\/mhindle\/publications\/\">publications<\/a> page which lists our latest papers, we have published two review papers, the first describes the use of CFD in modeling respiratory deposition:<\/p>\n\n\n\n<p>Longest PW, Bass K, Dutta R, Rani V, Thomas ML, El-Achwah A, Hindle M: \u201cUse of computational fluid dynamics deposition modeling in respiratory drug delivery\u201d, Expert Opin Drug Deliv. 21 Nov 2018, PMID: 30463458 DOI: 10.1080\/17425247.2019.1551875.<\/p>\n\n\n\n<p>And the second looks at add on devices to improve the performance of nebulizers:<\/p>\n\n\n\n<p>Longest W, Spence B, Hindle M. Devices for Improved Delivery of Nebulized Pharmaceutical Aerosols to the Lungs. J Aerosol Med Pulm Drug Deliv. 2019 Jul 9. doi: 10.1089\/jamp.2018.1508. [Epub ahead of print].<\/p>\n\n\n\n<p>Just to prove its not all work, we enjoyed celebrating with Varsha Nair her successful defense of her Masters Thesis. Varsha will join my lab to gain some formulation development and aerosol testing experience following graduation.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2019\/10\/IMG_20190711_202152.gif\" alt=\"\" class=\"wp-image-593 lazyload\" width=\"838\" height=\"471\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 838px; --smush-placeholder-aspect-ratio: 838\/471;\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Spring and Summer 2019 have been very busy and productive for the lab. We said good bye, good luck and thanks to Dr. Sneha Dhapare who was recruited to join the US FDA. In February and March, we welcomed two new Post Docs into the lab. Dr. Mohammad Momin joined from Dr. Shyamal Das&#8217;s lab [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3],"class_list":["post-513","post","type-post","status-publish","format-standard","hentry","category-news","tag-in-the-news"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/comments?post=513"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/513\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/media?parent=513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/categories?post=513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/tags?post=513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":511,"date":"2019-10-25T14:36:28","date_gmt":"2019-10-25T14:36:28","guid":{"rendered":"https:\/\/blogs.vcu.edu\/mhindle\/?p=511"},"modified":"2021-11-23T16:15:28","modified_gmt":"2021-11-23T16:15:28","slug":"alumni-visit","status":"publish","type":"post","link":"https:\/\/blogs.vcu.edu\/mhindle\/2019\/10\/25\/alumni-visit\/","title":{"rendered":"Alumni Visit"},"content":{"rendered":"\n<p>It was our great pleasure to host a visit by some of our alumni recently.<\/p>\n\n\n\n<p>Swati, Deepika, Bhawana and Renish joined the Aerosol Research Group for our Discussion Group meeting to re-live the memories of the weekly session where students and faculty discuss (or be interrogated) on their research. And it was great to have Dr. Byron join us for an afternoon of touring the Smith Building and re-visiting their &#8220;happy&#8217; graduate student days.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1440\" height=\"1080\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2019\/10\/IMG_0664.jpg\" alt=\"\" class=\"wp-image-588 lazyload\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1440px; --smush-placeholder-aspect-ratio: 1440\/1080;\" \/><\/figure>\n\n\n\n<p>It was a great opportunity for our graduate students and post-docs to see and interact with our successful alumni. We are very proud of their success and even happier that they were able to take the time to come down to Richmond and visit.<\/p>\n\n\n\n<p>The afternoon was ended with a trip to Legends and a chance for more discussion and laughter. Thanks for visiting and you are always welcome to come back anytime.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" data-src=\"https:\/\/blogs.vcu.edu\/mhindle\/wp-content\/uploads\/sites\/10\/2019\/10\/P_20190222_171630.gif\" alt=\"\" class=\"wp-image-591 lazyload\" width=\"833\" height=\"609\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 833px; --smush-placeholder-aspect-ratio: 833\/609;\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>It was our great pleasure to host a visit by some of our alumni recently. Swati, Deepika, Bhawana and Renish joined the Aerosol Research Group for our Discussion Group meeting to re-live the memories of the weekly session where students and faculty discuss (or be interrogated) on their research. And it was great to have [&hellip;]<\/p>\n","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3],"class_list":["post-511","post","type-post","status-publish","format-standard","hentry","category-news","tag-in-the-news"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/comments?post=511"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/posts\/511\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/media?parent=511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/categories?post=511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.vcu.edu\/mhindle\/wp-json\/wp\/v2\/tags?post=511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}]