[{"id":545,"date":"2023-01-03T19:54:14","date_gmt":"2023-01-03T19:54:14","guid":{"rendered":"https:\/\/blogs.vcu.edu\/lellwein\/?page_id=545"},"modified":"2024-08-27T19:11:59","modified_gmt":"2024-08-27T19:11:59","slug":"opportunities","status":"publish","type":"page","link":"https:\/\/blogs.vcu.edu\/lellwein\/opportunities\/","title":{"rendered":"Opportunities"},"content":{"rendered":"\n<p><a href=\"https:\/\/virginiacommonwealth.instructure.com\/courses\/88467\">Math Department: Advising and Career Resources<\/a><\/p>\n\n\n\n<p><strong>Jobs!<\/strong> <strong>(This is an excerpt from Handshake with &#8220;math&#8221; in job descriptions)<\/strong><\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\"><ul class=\"wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/vcu.joinhandshake.com\/jobs\/10998021\/share_preview'>Full-time Faculty (Multiple Disciplinary fields included) at Bard Early Colleges \/ Bard High School Early College (Headquarters)<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/vcu.joinhandshake.com\/jobs\/10997780\/share_preview'>Statistical Scientist (M.S. or Ph.D.) at Exponent<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/vcu.joinhandshake.com\/jobs\/10997779\/share_preview'>Data &amp; Cloud Solutions Engineer (M.S. or Ph.D.) at Exponent<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/vcu.joinhandshake.com\/jobs\/10997690\/share_preview'>Wisconsin Math Tutor at Ampact<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/vcu.joinhandshake.com\/jobs\/10997243\/share_preview'>Entry-Level Trial Master File [TMF] Document Administrator at Medpace, Inc.<\/a><\/div><\/li><\/ul><\/div><\/div>\n\n\n\n<p>More at <a href=\"https:\/\/vcu.joinhandshake.com\/stu\">Handshake<\/a><\/p>\n\n\n\n<p><strong><a href=\"https:\/\/link.vcu.edu\/\" data-type=\"link\" data-id=\"https:\/\/link.vcu.edu\/\">VCU Link<\/a><\/strong><\/p>\n\n\n\n<p><a href=\"http:\/\/VCU Student Opportunity Center\" data-type=\"URL\" data-id=\"http:\/\/VCU Student Opportunity Center\">VCU Student Opportunity Center<\/a><br>(Set up keywords and get weekly alerts)<\/p>\n\n\n\n<p><a href=\"https:\/\/www.schooljobs.com\/careers\/chesterfieldschools\">Tutoring (middle school math) with Chesterfield County Public Schools<\/a><br>(do a search for &#8220;Middle School Math TWA&#8221; or look at other teaching positions)<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Math Department: Advising and Career Resources Jobs! (This is an excerpt from Handshake with &#8220;math&#8221; in job descriptions) More at Handshake VCU Link VCU Student Opportunity Center(Set up keywords and get weekly alerts) Tutoring (middle school math) with Chesterfield County Public Schools(do a search for &#8220;Middle School Math TWA&#8221; or look at other teaching positions)<\/p>\n","protected":false},"author":432,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-545","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/users\/432"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/comments?post=545"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/545\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/media?parent=545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":243,"date":"2018-04-23T15:41:30","date_gmt":"2018-04-23T15:41:30","guid":{"rendered":"http:\/\/wp.vcu.edu\/lellwein\/?page_id=243"},"modified":"2026-04-21T14:18:40","modified_gmt":"2026-04-21T14:18:40","slug":"students","status":"publish","type":"page","link":"https:\/\/blogs.vcu.edu\/lellwein\/students\/","title":{"rendered":"Students"},"content":{"rendered":"<p>Helen Harris is working on a dynamic model of the interaction of the HPA axis (cortisol) with catecholamines. She is a co-author on an accepted manuscript on this project, and another manuscript on a project analyzing medication reconciliation. Harris received her MS in spring 2023 and just defended her dissertation in Spring 2026 in VCU&#8217;s <a href=\"https:\/\/sysm.vcu.edu\/\">Systems Modeling and Analysis PhD program.<\/a> Congradulations Dr. Harris!<\/p>\n<p>Richard Foster received a VCU Undergraduate Research Summer Fellowship (<a href=\"https:\/\/provost.vcu.edu\/initiatives\/urop\/urop-fellowship\/\">UROP<\/a>) for Summer 2020. He is a co-author on two peer-reviewed publications of models of breathing in preterm infants. Foster received his MS in spring 2023 and just defended his dissertation in Spring 2026 in VCU&#8217;s <a href=\"https:\/\/sysm.vcu.edu\/\">Systems Modeling and Analysis PhD program<\/a>. Congratulations Dr. Foster!<\/p>\n<p>Kylee Hartman-Caballero successfully defended her MS thesis titled &#8220;Penalized Interpolating B-splines and Their Applications&#8221; on April 25, 2024. She is enrolled in a PhD program at Old Dominion University. Congratulations Kylee!<\/p>\n<p>Mariana Fernandes Gragnini received a VCU Undergraduate Research Summer Fellowship (<a href=\"https:\/\/provost.vcu.edu\/initiatives\/urop\/urop-fellowship\/\">UROP<\/a>) for Summer 2021. She started to develop a model of cerebrovascular resistance as a function of partial pressure of carbon dioxide. Fernandes Gragnini graduated with a double-major in applied mathematics and biomedical engineering, and as of 2026 is a medical student at VCU School of Medicine.<\/p>\n<p>Jeff Evans received a VCU Undergraduate Research Summer Fellowship (<a href=\"https:\/\/research.vcu.edu\/ugresources\/opps.htm\">UROP<\/a>) for Summer 2018. He investigated the impact of a set of different diaphragm pressure driving functions in a model of preterm infant breathing. Evans graduated from VCU with an MS in Mathematics in 2021.<\/p>\n<p>Lauren Linkous worked under a VCU College of Humanities and Sciences Faculty Council Award in Summer 2016. She performed a stability analysis on a model of preterm infant breathing and is a co-author on a <a href=\"https:\/\/blogs.vcu.edu\/lellwein\/publications\/\">published manuscript<\/a>. Linkous received her PhD in Electrical Engineering from VCU in 2024.<\/p>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Helen Harris is working on a dynamic model of the interaction of the HPA axis (cortisol) with catecholamines. She is a co-author on an accepted manuscript on this project, and another manuscript on a project analyzing medication reconciliation. Harris received her MS in spring 2023 and just defended her dissertation in Spring 2026 in VCU&#8217;s [&hellip;]<\/p>\n","protected":false},"author":432,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-243","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/243","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/users\/432"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/comments?post=243"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/243\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/media?parent=243"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":136,"date":"2016-08-25T16:25:02","date_gmt":"2016-08-25T16:25:02","guid":{"rendered":"http:\/\/wp.vcu.edu\/lellwein\/?page_id=136"},"modified":"2024-04-26T21:36:22","modified_gmt":"2024-04-26T21:36:22","slug":"biomathematics-seminar","status":"publish","type":"page","link":"https:\/\/blogs.vcu.edu\/lellwein\/biomathematics-seminar\/","title":{"rendered":"Biomath Seminar"},"content":{"rendered":"<p>Please see the past Spring 2024 schedule below.<\/p>\n<p><a href=\"https:\/\/math.vcu.edu\/events\/biomath-seminar\/\">Biomath Seminar, Spring 2024<\/a><\/p>\n\n\n<p>Organizers:<br>Oyita Udiani (udianio@vcu.edu)<br>Laura Ellwein Fix (lellwein@vcu.edu)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Please see the past Spring 2024 schedule below. Biomath Seminar, Spring 2024 Organizers:Oyita Udiani (udianio@vcu.edu)Laura Ellwein Fix (lellwein@vcu.edu)<\/p>\n","protected":false},"author":432,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-136","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/users\/432"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/comments?post=136"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/136\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/media?parent=136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":109,"date":"2016-07-29T15:41:45","date_gmt":"2016-07-29T15:41:45","guid":{"rendered":"http:\/\/wp.vcu.edu\/lellwein\/?page_id=109"},"modified":"2022-09-08T18:23:55","modified_gmt":"2022-09-08T18:23:55","slug":"contact-me","status":"publish","type":"page","link":"https:\/\/blogs.vcu.edu\/lellwein\/contact-me\/","title":{"rendered":"Contact"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-537\" src=\"https:\/\/blogs.vcu.edu\/lellwein\/wp-content\/uploads\/sites\/287\/2022\/09\/LauraEllweinFix_Portrait_2022-crop.jpg\" alt=\"\" width=\"173\" height=\"263\" \/><\/p>\n<p><a href=\"http:\/\/www.math.vcu.edu\" target=\"_blank\" rel=\"noopener noreferrer\">Department of Mathematics and Applied Mathematics<\/a><br \/>\n<a href=\"http:\/\/www.vcu.edu\" target=\"_blank\" rel=\"noopener noreferrer\">Virginia Commonwealth University<\/a><br \/>\n1015 Floyd Ave.<br \/>\nRichmond, VA 23220<br \/>\nW: 804 \/ 828-2748<br \/>\nF: 804 \/ 828-8785<br \/>\n<a href=\"mailto:lellwein@vcu.edu\" target=\"_blank\" rel=\"noopener noreferrer\">lellwein@vcu.edu<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Department of Mathematics and Applied Mathematics Virginia Commonwealth University 1015 Floyd Ave. Richmond, VA 23220 W: 804 \/ 828-2748 F: 804 \/ 828-8785 lellwein@vcu.edu<\/p>\n","protected":false},"author":432,"featured_media":0,"parent":0,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-109","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/users\/432"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/comments?post=109"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/109\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/media?parent=109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":57,"date":"2016-07-01T15:50:58","date_gmt":"2016-07-01T15:50:58","guid":{"rendered":"http:\/\/wp.vcu.edu\/lellwein\/?page_id=57"},"modified":"2026-03-03T19:57:53","modified_gmt":"2026-03-03T19:57:53","slug":"bio","status":"publish","type":"page","link":"https:\/\/blogs.vcu.edu\/lellwein\/","title":{"rendered":"Welcome!"},"content":{"rendered":"\n<p>Our group develops mathematical models to simulate and analyze dynamics in cardiopulmonary physiology, including simulations of transport processes and control in response to system disturbances. We are particularly motivated by the use of patient-specific and often non-invasive data to predict behavior at the individual level. Our work spans scales from lumped parameter systems of differential equations to three-dimensional distributed parameter fluid dynamics simulations. This work is highly interdisciplinary and as a result we collaborate with researchers in biomedical engineering, medicine, and exercise science.<\/p>\n\n\n\n<p><em>Take a look through <a href=\"https:\/\/blogs.vcu.edu\/lellwein\/research\/\">our research page<\/a> for current projects and opportunities.<\/em><\/p>\n\n\n\n<p>I am an associate professor at VCU in the <a href=\"http:\/\/math.vcu.edu\" data-type=\"link\" data-id=\"math.vcu.edu\">Department of Mathematics and Applied Mathematics<\/a> and currently hold the roles of Associate Chair and Director of Undergraduate Programs within the department. I am an active part of the department&#8217;s research group in <a href=\"https:\/\/math.vcu.edu\/research\/mathematical-biology\/\">Mathematical Biology<\/a>. Prior to VCU&nbsp;I held a postdoctoral fellowship at Marquette University awarded by the American Heart Association working in the biomedical engineering lab of&nbsp;<a href=\"https:\/\/childrenswi.org\/physician-directory\/researchers\/john-ladisa\">John F. LaDisa, Jr<\/a> (now at Children&#8217;s Hospital of Wisconsin). I received my PhD in 2008 in applied mathematics from North Carolina State University under <a href=\"https:\/\/olufsen.wordpress.ncsu.edu\/\">Mette S. Olufsen<\/a> with concentrations in physiology and computational mathematics. I also have a BS in chemical engineering from the University of Wisconsin &#8211; Madison. In the four years before graduate school, I worked as a quality engineer for General Mills.  <\/p>\n\n\n\n<div class=\"wp-block-file\"><a id=\"wp-block-file--media-3d2256e4-8903-4d4b-9b10-a0dc417e9518\" href=\"https:\/\/blogs.vcu.edu\/lellwein\/wp-content\/uploads\/sites\/287\/2026\/03\/lellweinCV_spring26.pdf\">lellweinCV_spring26<\/a><a href=\"https:\/\/blogs.vcu.edu\/lellwein\/wp-content\/uploads\/sites\/287\/2026\/03\/lellweinCV_spring26.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-3d2256e4-8903-4d4b-9b10-a0dc417e9518\">Download<\/a><\/div>\n\n\n\n<p class=\"has-large-font-size\"><strong><mark style=\"background-color:#fcb900\" class=\"has-inline-color has-black-color\">Jobs!<\/mark><\/strong><\/p>\n\n\n<ul class=\"wp-block-rss\"><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/vcu.joinhandshake.com\/jobs\/10998021\/share_preview'>Full-time Faculty (Multiple Disciplinary fields included) at Bard Early Colleges \/ Bard High School Early College (Headquarters)<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/vcu.joinhandshake.com\/jobs\/10997780\/share_preview'>Statistical Scientist (M.S. or Ph.D.) at Exponent<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/vcu.joinhandshake.com\/jobs\/10997779\/share_preview'>Data &amp; Cloud Solutions Engineer (M.S. or Ph.D.) at Exponent<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/vcu.joinhandshake.com\/jobs\/10997690\/share_preview'>Wisconsin Math Tutor at Ampact<\/a><\/div><\/li><li class='wp-block-rss__item'><div class='wp-block-rss__item-title'><a href='https:\/\/vcu.joinhandshake.com\/jobs\/10997243\/share_preview'>Entry-Level Trial Master File [TMF] Document Administrator at Medpace, Inc.<\/a><\/div><\/li><\/ul>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our group develops mathematical models to simulate and analyze dynamics in cardiopulmonary physiology, including simulations of transport processes and control in response to system disturbances. We are particularly motivated by the use of patient-specific and often non-invasive data to predict behavior at the individual level. Our work spans scales from lumped parameter systems of differential [&hellip;]<\/p>\n","protected":false},"author":432,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-57","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/57","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/users\/432"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/comments?post=57"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/57\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/media?parent=57"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":27,"date":"2016-05-11T20:48:06","date_gmt":"2016-05-11T20:48:06","guid":{"rendered":"http:\/\/wp.vcu.edu\/lellwein\/?page_id=27"},"modified":"2026-03-03T19:21:46","modified_gmt":"2026-03-03T19:21:46","slug":"publications","status":"publish","type":"page","link":"https:\/\/blogs.vcu.edu\/lellwein\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<p><a href=\"https:\/\/scholar.google.com\/citations?user=V8dr_1YAAAAJ&amp;hl=en\"><span style=\"color: #ff00ff\"><strong>Google Scholar page<\/strong><\/span><\/a><\/p>\n<p><strong>Manuscripts under Review<\/strong><\/p>\n<p><strong>Manuscripts In Progress<\/strong><\/p>\n<p>Harris H and\u00a0<strong>Ellwein Fix L. <\/strong>A closed-loop model of dependence of cerebrovascular reactivity on inhaled carbon dioxide.<\/p>\n<p><strong>Refereed Publications and Proceedings<\/strong><\/p>\n<p>23. Harris H, Chan D, <strong>Ellwein Fix L<\/strong>, Nicholson B, Acevedo E. (2026) Subject-specific modeling of response to physical stress via hypothalamic-pituitary-adrenal and sympathoadrenal axes. <em>Accepted to PLoS One<\/em>, March 2026.<\/p>\n<p>22. Foster R, <strong>Ellwein Fix L<\/strong>. (2025) <span class=\"il\">Practical<\/span> parameter identifiability of respiratory mechanics in the extremely preterm infant. <em>Royal Society Philosophical Transactions A, <\/em>Available online 02 April 2025, <a href=\"https:\/\/doi.org\/10.1098\/rsta.2024.0226\">https:\/\/doi.org\/10.1098\/rsta.2024.0226<\/a>.<\/p>\n<p>21. Harris H, Chan D, <strong>Ellwein Fix L<\/strong>, Chouinard M, Salgado T, Kang, Le, Bearman G. (2025) Incremental Benefit of Medication Reconciliation Practices on Patient Health Outcomes in a Healthcare Setting. <em>The Joint Commission Journal on Quality and Patient Safety,\u00a0<\/em>Available online 19 February 2025, <a href=\"https:\/\/doi.org\/10.1016\/j.jcjq.2025.02.001\">https:\/\/doi.org\/10.1016\/j.jcjq.2025.02.001<\/a><\/p>\n<p>20. Luke, R.A., Kelly, G., Stoner, M., O\u2019Brien, J.E., Lubkin, S.R., <strong>Ellwein Fix, L.<\/strong> (2024). Towards a Mathematical Understanding of Ventilator-Induced Lung Injury in Preterm Rat Pups. In: Ford Versypt, A.N., Segal, R.A., Sindi, S.S. (eds) <em>Mathematical Modeling for Women\u2019s Health. The IMA Volumes in Mathematics and its Applications<\/em>, vol 166, pp.167-211. Springer, Cham. <a href=\"https:\/\/doi.org\/10.1007\/978-3-031-58516-6_6\">https:\/\/doi.org\/10.1007\/978-3-031-58516-6_6<\/a><\/p>\n<p>19. Foster R, Smith B, <strong>Ellwein Fix L.<\/strong> (2023) Thoracoabdominal asynchrony in a virtual preterm infant: computational modeling and analysis. <em>Am J Physiol Lung Cell Mol Physiol, <\/em>325(2): L190-L205. <a href=\"https:\/\/journals.physiology.org\/doi\/abs\/10.1152\/ajplung.00123.2022\">https:\/\/journals.physiology.org\/doi\/abs\/10.1152\/ajplung.00123.2022<\/a> (IF=6.011)<\/p>\n<p>18. <strong>Ellwein Fix, Laura<\/strong>; Filippas, Afroditi; Brucal-Hallare, Maila; and Segal, Rebecca (2022) &#8220;Improving Student Knowledge Transfer between Mathematics and Engineering Courses through Structured Cross-disciplinary Collaboration: A SUMMIT-P Initiative,&#8221; <em>Journal of Mathematics and Science: Collaborative Explorations<\/em>: Vol. 18: No. 1, Article 4. <a href=\"https:\/\/scholarscompass.vcu.edu\/jmsce_vamsc\/vol18\/iss1\/4\">https:\/\/scholarscompass.vcu.edu\/jmsce_vamsc\/vol18\/iss1\/4<\/a><\/p>\n<p>17. Colebank MJ, Paun M, Qureshi MU, Chesler N, Husmeier D, Olufsen MS, <strong>Ellwein Fix L. <\/strong>(2019) Influence of image segmentation on one-dimensional fluid dynamics predictions in the mouse pulmonary arteries.<em>\u00a0J R Soc Interface<\/em>,<br \/>\n<a href=\"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsif.2019.0284\">https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsif.2019.0284<\/a> (IF= 4.118)<\/p>\n<p class=\"header\">16. Qureshi MU, Colebank MJ, Paun ML, <strong>Ellwein Fix L<\/strong>, Chesler N, Haider MA, Hill NA, Husmeier D, Olufsen MS. (2019). Hemodynamic assessment of pulmonary hypertension in mice &#8212; a model-based analysis of the disease mechanism. <em>Biomech Model Mechanobiol<\/em>, 18(1):219-243,\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s10237-018-1078-8\">https:\/\/doi.org\/10.1007\/s10237-018-1078-8<\/a> (IF=3.323)<\/p>\n<p class=\"header\">15.<strong> Ellwein Fix L<\/strong>, El Khoury J, Moores R Jr., Linkous L, Brandes M, Rozycki H. (2018). Theoretical open-loop model of respiratory mechanics in the preterm neonate. <em>PLoS ONE<\/em>,\u00a0<a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0198425\">https:\/\/doi.org\/10.1371\/journal.pone.0198425<\/a>\u00a0\u00a0(IF=2.806)<\/p>\n<p class=\"header\">14. <strong>Ellwein L<\/strong>, Samyn M, Danduran M, Schindler-Ivens S, Liebham S, LaDisa Jr. JF. (2017) Toward translating near-infrared spectroscopy oxygen saturation data for the non-invasive prediction of spatial and temporal hemodynamics during exercise. <em>Biomech Model Mechanobiol<\/em>, 16(1):75-96. <a href=\"https:\/\/doi.org\/10.1007\/s10237-016-0803-4\">https:\/\/doi.org\/10.1007\/s10237-016-0803-4<\/a> (IF=3.323)<\/p>\n<p>13. <strong>Ellwein L<\/strong>, Marks DS, Migrino RQ, Foley WD, Sherman S, LaDisa JF Jr. (2016) Image-based quantification of 3-D morphology for bifurcations in the left coronary artery: application to stent design. <em>Cathet Cardiovasc Intervent<\/em>, 87(7):1244-55. <a href=\"https:\/\/doi.org\/10.1002\/ccd.26247\">https:\/\/doi.org\/10.1002\/ccd.26247<\/a> (IF=2.602)<\/p>\n<p id=\"e11\">12. Ford Versypt AN, Makrides E, Arciero J, <strong>Ellwein L<\/strong>, Layton AT. (2015) Bifurcation study of blood flow control in the kidney. <em>Math Biosci<\/em>, 263:169-179. <a href=\"https:\/\/doi.org\/10.1016\/j.mbs.2015.02.015\">https:\/\/doi.org\/10.1016\/j.mbs.2015.02.015<\/a> (IF=1.246)<\/p>\n<p>11. Quam DJ, Gundert TJ, Migrino RQ, Otake H, <strong>Ellwein L<\/strong>, Hayden P, LaDisa JF, Jr. (2015) Immersive visualization for enhanced computational fluid dynamics analysis. <em>J Biomech Eng<\/em>, 137(3):031004.\u00a0<a href=\"https:\/\/dx.doi.org\/10.1115%2F1.4029017\">https:\/\/dx.doi.org\/10.1115%2F1.4029017<\/a> (IF=2.057)<\/p>\n<div id=\"e5\">\n<p>10. Arciero J, <strong>Ellwein L<\/strong>, Ford Versypt AN, Makrides E, Layton AT. (2014) Modeling blood flow control in the kidney. In: Jackson T, Radunskaya A (Eds) <em>Applications of Dynamical Systems in Biology and Medicine (Vol 158, pp.55-73). The IMA Volumes in Mathematics and its Applications.<\/em>\u00a0Springer New York.\u00a0<a href=\"https:\/\/doi.org\/10.1007\/978-1-4939-2782-1_3\">https:\/\/doi.org\/10.1007\/978-1-4939-2782-1_3<\/a><\/p>\n<p>9. <strong>Ellwein LM<\/strong>, LaDisa JF, Jr., Leibham S, Schindler-Ivens S, Samyn M. (2013) Quantification of thoracic aorta blood flow by magnetic resonance imaging during supine cycling exercise of increasing intensity. <em>J Cardiov Magn Reson<\/em>, 15 (Suppl 1):P239.\u00a0\u00a0<a href=\"https:\/\/doi.org\/10.1186\/1532-429X-15-S1-P239\">https:\/\/doi.org\/10.1186\/1532-429X-15-S1-P239<\/a>\u00a0\u00a0(IF=5.601)<\/p>\n<p>8. <strong>Ellwein LM<\/strong>, Pope S, Xie A, Batzel JJ, Kelley CT, Olufsen MS. (2013) Patient-specific modeling of cardiovascular and respiratory dynamics during hypercapnia. <em>Math Biosci<\/em>, 241:56-74. <a href=\"https:\/\/dx.doi.org\/10.1016%2Fj.mbs.2012.09.003\">https:\/\/dx.doi.org\/10.1016%2Fj.mbs.2012.09.003<\/a> (IF=1.246)<\/p>\n<p>7. Wendell DC, Samyn MM, Cava JR, <strong>Ellwein LM<\/strong>, Krolikowski MM, Gandy KL, Pelech AN, Shadden SC, LaDisa JF. (2013) Including aortic valve morphology in computational fluid dynamics simulations: initial findings and application to aortic coarctation. <em>Med Eng Phys<\/em>, 35(6):723-735.\u00a0<a href=\"https:\/\/dx.doi.org\/10.1016%2Fj.medengphy.2012.07.015\">https:\/\/dx.doi.org\/10.1016%2Fj.medengphy.2012.07.015<\/a> (IF=1.819)<\/p>\n<p>6. Batzel JJ, <strong>Ellwein LM<\/strong>, Olufsen MS. (2011) Modeling cardio-respiratory system response to inhaled CO2 in patients with congestive heart failure. <em>Proc 33rd Ann Inter Conf IEEE\/EMBC<\/em>, Boston: 2418-2421.<br \/>\n<a href=\"https:\/\/doi.org\/10.1109\/IEMBS.2011.6090673\">https:\/\/doi.org\/10.1109\/IEMBS.2011.6090673<\/a><\/p>\n<p>5. <strong>Ellwein LM<\/strong>, Otake H, Gundert TJ, Koo B-K, Shinke T, Honda Y, Shite J, Ladisa JF, Jr. (2011) Optical coherence tomography for patient-specific 3D artery reconstruction and evaluation of wall shear stress in a left circumflex coronary artery. <em>Cardiovasc Eng Technol<\/em>, 2(3): 212-227.\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s13239-011-0047-5\">https:\/\/doi.org\/10.1007\/s13239-011-0047-5<\/a> (IF=1.064)<\/p>\n<p>4. LaDisa JF, Jr., Figueroa CA, Vignon-Clementel IE, Kim HJ, Xiao N, <strong>Ellwein LM<\/strong>, Chan FP, Feinstein JA, Taylor CA. (2011) Computational simulations for aortic coarctation: representative results from a sampling of patients. <em>J Biomech Eng<\/em>. 133(9):091008. <a href=\"http:\/\/dx.doi.org\/10.1115\/1.4004996\">http:\/\/dx.doi.org\/10.1115\/1.4004996<\/a> (IF=2.057)<\/p>\n<p>3. Pope SR, <strong>Ellwein LM<\/strong>, Zapata CL, Novak V, Kelley CT, Olufsen MS. (2009) Estimation and identification of parameters in a lumped cerebrovascular model. <em>Math Biosci Eng<\/em>, 6(1):93-115. <a href=\"http:\/\/dx.doi.org\/10.3934\/mbe.2009.6.93\">http:\/\/dx.doi.org\/10.3934\/mbe.2009.6.93<\/a> (IF=1.035)<\/p>\n<p>2. <strong>Ellwein LM<\/strong>, Tran H, Zapata CL, Novak V, Olufsen MS. (2008) Sensitivity analysis and model assessment: mathematical models for arterial blood flow and blood pressure. <em>J Cardio Eng<\/em>, 8(2):94-108.\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s10558-007-9047-3\">https:\/\/doi.org\/10.1007\/s10558-007-9047-3<\/a>\u00a0 (IF= 2.5 (RG))<\/p>\n<p>1. Olufsen MS, Ottesen JT, Tran HT, <strong>Ellwein LM<\/strong>, Lipsitz LA, Novak V. (2005) Blood pressure and blood flow variation during postural change from sitting to standing &#8211; modeling and experimental validation. <em>J Appl Physiol<\/em>, 99(4):1523-1537.\u00a0<a href=\"https:\/\/dx.doi.org\/10.1152%2Fjapplphysiol.00177.2005\">https:\/\/dx.doi.org\/10.1152%2Fjapplphysiol.00177.2005<\/a>\u00a0 (IF=3.351)<\/p>\n<\/div>\n<p><strong>Manuscripts in Preparation<\/strong><\/p>\n<p>Aleiou A, Otake H, Hughey JK, Arzani A,\u00a0 <strong>Ellwein Fix L<\/strong>, LaDisa JF, Jr. Association between post-stenting patient-specific wall shear stress indices and precursors of restenosis or late stent thrombosis after drug-eluting stent implantation. (Manuscript in preparation)<\/p>\n<p>Filippas A, Segal R, <strong>Ellwein Fix L<\/strong>, Karles T. (2022) Interdisciplinary collaboration to improve knowledge transfer between mathematics and engineering. (Manuscript in preparation)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Google Scholar page Manuscripts under Review Manuscripts In Progress Harris H and\u00a0Ellwein Fix L. A closed-loop model of dependence of cerebrovascular reactivity on inhaled carbon dioxide. Refereed Publications and Proceedings 23. Harris H, Chan D, Ellwein Fix L, Nicholson B, Acevedo E. (2026) Subject-specific modeling of response to physical stress via hypothalamic-pituitary-adrenal and sympathoadrenal axes. [&hellip;]<\/p>\n","protected":false},"author":432,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-27","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/27","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/users\/432"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/comments?post=27"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/27\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/media?parent=27"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":20,"date":"2016-05-11T20:41:30","date_gmt":"2016-05-11T20:41:30","guid":{"rendered":"http:\/\/wp.vcu.edu\/lellwein\/?page_id=20"},"modified":"2026-03-03T19:53:19","modified_gmt":"2026-03-03T19:53:19","slug":"teaching","status":"publish","type":"page","link":"https:\/\/blogs.vcu.edu\/lellwein\/teaching\/","title":{"rendered":"Teaching"},"content":{"rendered":"<div id=\"e2\" class=\"cc11\">\n<p><strong>Virginia Commonwealth University (Fall 2012 &#8212; present)<\/strong><\/p>\n<p><em style=\"font-size: 1rem\">Associate Professor, 2019 &#8211; present<br \/>\n<\/em><em style=\"font-size: 1rem\">Assistant Professor, 2012 &#8211; 2019<\/em><\/p>\n<p><span style=\"text-decoration: underline\">Grants and Awards<\/span><\/p>\n<p>Reuben Farley Award for Teaching Innovation and Excellence (VCU Math), 2025<br \/>\nVCU Libraries Affordable Course Content Award, 2024<\/p>\n<p><span style=\"text-decoration: underline\">Courses Taught<\/span><\/p>\n<\/div>\n<div class=\"cc13\">MATH 255: Introduction to Computational Mathematics &#8212; S16, F16, S18, S19, F20<\/div>\n<div id=\"e1\" class=\"cc13\">MATH 301: Differential Equations &#8212; F12 x2, F13, F15, F17, F19, F21, F23 x2, F24<\/div>\n<div class=\"cc13\">MATH 380: Introduction to Mathematical Biology &#8212; F17, S18, S21<br \/>\nMATH 433 (prev. 533): Partial Differential Equations I\u00a0&#8212; S13, S14 x2, S15, S16, S17<\/div>\n<div class=\"cc13\">MATH 435 (prev. 391): Mathematical and Computational Modeling &#8212; S19, <span style=\"color: #000000\">S20, S23<\/span><br \/>\nMATH 415: Numerical Methods &#8212; F18, F19, F21, S24, S26<\/div>\n<div class=\"cc13\">MATH 490: Mathematical Expositions &#8212; <span style=\"color: #000000\">S20<\/span><br \/>\nMATH 515: Numerical Analysis I &#8212; F13, S23, S24<\/div>\n<div class=\"cc13\">MATH 585: Biomathematics Seminar: Physiological Modeling &#8212; S15, S17, S19, F23, S25<br \/>\n<span style=\"font-size: revert;color: initial\">MATH 615: Numerical Analysis (graduate) &#8212; F15, F16, F18, F20, F22<br \/>\n<\/span><span style=\"font-size: revert;color: initial\">MATH 690: Research Seminar &#8212; S21, S25<br \/>\n<\/span><span style=\"font-size: revert;color: initial\">MATH 769: Topics in Applied Mathematics: Parameter Estimation &#8212; F22, F25<\/span><\/div>\n<div class=\"cc13\"><a href=\"http:\/\/bulletin.vcu.edu\/azcourses\/math\/\" target=\"_blank\" rel=\"noopener noreferrer\">VCU Course Bulletin<\/a><\/div>\n<div class=\"cc13\">\n<hr \/>\n<\/div>\n<div class=\"cc13\">\n<div id=\"e16\" class=\"cc11\">\n<p><strong>North Carolina State University (Fall 2003 &#8212; Spring 2008)<\/strong><\/p>\n<\/div>\n<div id=\"e15\" class=\"cc12\"><em>Instructor<br \/>\n<\/em><span style=\"font-size: 1rem\">MA 111: Precalculus Algebra and Trigonometry<\/span><em><br \/>\n<\/em><\/div>\n<div id=\"e14\" class=\"cc13\">MA 121: Elements of Calculus<br \/>\nMA 231: Calculus for Life and Management Sciences B<br \/>\nMA 241: Calculus II<\/div>\n<div id=\"e13\" class=\"cc12\"><em>Guest Lecturer<\/em><\/div>\n<div class=\"cc12\">MA 432: Mathematical Models in Life and Social Sciences<\/div>\n<div id=\"e12\" class=\"cc13\">\n<hr \/>\n<p><strong>Marquette University (Fall 2008 &#8212; Summer 2012)<\/strong><\/p>\n<p><em>Guest Lecturer<br \/>\n<\/em>BIEN 4400\/5400: Transport Phenomena<br \/>\nBIEN 4720\/5720: Cardiopulmonary Mechanics<br \/>\nBIEN 5320: Biomedical Instrumentation Design<\/p>\n<\/div>\n<div class=\"cc13\"><em>Lab Coordinator<\/em><br \/>\nBIEN 4400\/5400: Transport Phenomena<\/div>\n<div id=\"e7\" class=\"cc13\">\n<hr \/>\n<\/div>\n<div class=\"cc13\">\n<p><strong>Milwaukee School of Engineering (Fall 2010 &#8212; Spring 2012)<\/strong><\/p>\n<\/div>\n<div id=\"e5\" class=\"cc13\"><em>Adjunct Faculty<\/em><\/div>\n<div class=\"cc13\">MA125: Algebra I<br \/>\nMA127: Algebra II<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Virginia Commonwealth University (Fall 2012 &#8212; present) Associate Professor, 2019 &#8211; present Assistant Professor, 2012 &#8211; 2019 Grants and Awards Reuben Farley Award for Teaching Innovation and Excellence (VCU Math), 2025 VCU Libraries Affordable Course Content Award, 2024 Courses Taught MATH 255: Introduction to Computational Mathematics &#8212; S16, F16, S18, S19, F20 MATH 301: Differential [&hellip;]<\/p>\n","protected":false},"author":432,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-20","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/20","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/users\/432"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/comments?post=20"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/20\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/media?parent=20"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}},{"id":6,"date":"2016-05-11T20:18:55","date_gmt":"2016-05-11T20:18:55","guid":{"rendered":"http:\/\/wp.vcu.edu\/lellwein\/?page_id=6"},"modified":"2026-04-21T14:19:37","modified_gmt":"2026-04-21T14:19:37","slug":"research","status":"publish","type":"page","link":"https:\/\/blogs.vcu.edu\/lellwein\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<p style=\"text-align: left\"><strong>INTERESTS<br \/>\n<\/strong>Modeling of regulation in cardiovascular and pulmonary systems<br \/>\nDifferential equations and dynamical systems<br \/>\nData-driven patient-specific parameterization<br \/>\nNumerical methods and optimization in physiological systems<br \/>\nAlgorithm development for biomedical applications<br \/>\nComputational fluid dynamics<\/p>\n<p><strong>GRANTS AND AWARDS<\/strong><\/p>\n<p><strong>Seed Award (VCU)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong>Apr\u00a0 2024<em> \u00a0\u00a0\u00a0 Predictive Modeling of Cerebrovascular Reactivity.<\/em> PI: Laura Ellwein Fix.\u00a0Award: $5000 for student stipend and travel.<\/p>\n<p><strong>Faculty Council Research Award, College of Humanities and Sciences (VCU)<\/strong>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 May 2016 <em>Computational Modeling of Chest wall Rigidity<\/em>. PI: Laura Ellwein Fix, PhD.<\/p>\n<p><strong>Atlantic Pediatric Device Consortium, 5<sup>th<\/sup> Annual Innovation Competition Award.<\/strong>\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Oct 2015<br \/>\n<em>Improving Chest Wall Rigidity in Very Preterm Infants<\/em>. Co-PIs: Ku and Boyan. FDA #5P50FD004193-07, subaward GIT-RE159 to Henry Rozycki. Consultant: $3000.<\/p>\n<p style=\"text-align: left\"><strong>ONGOING PROJECTS (current collaboration opportunities marked by <img loading=\"lazy\" decoding=\"async\" class=\"wp-image-573 alignnone\" src=\"https:\/\/blogs.vcu.edu\/lellwein\/wp-content\/uploads\/sites\/287\/2023\/06\/11954231212059546365idea_yves_guillou_01.svg_.thumb_.png\" alt=\"\" width=\"24\" height=\"34\" \/>)<br \/>\n<\/strong><em>Interested in the <a href=\"https:\/\/sysm.vcu.edu\/\">Systems Modeling and Analysis PhD program<\/a>? Apply by Feb. 1 for the following academic year. Admissions are done centrally but you may express interest in particular faculty or projects.<\/em><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-573\" src=\"https:\/\/blogs.vcu.edu\/lellwein\/wp-content\/uploads\/sites\/287\/2023\/06\/11954231212059546365idea_yves_guillou_01.svg_.thumb_.png\" alt=\"\" width=\"24\" height=\"34\" \/>\u00a0Evaluation of Factors in Compromised Breathing in Preterm Infants using Pulmonary Dynamics Modeling<\/strong><br \/>\nHenry Rozycki MD; Joseph E. Khoury, MD; Russell Moore, MD; Matthew Brandes, PhD (MCV).<br \/>\nBradford Smith, PhD (CU-Anschutz).<br \/>\nStudents: Richard Foster, Jeffrey Evans, Lauren Linkous<\/p>\n<ul>\n<li>Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and<br \/>\nis associated with a lower risk of chronic lung disease. However, this mode is often not successful<br \/>\nin the extremely preterm infant in part due to the highly compliant (floppy) chest wall at this stage of gestation. A foundational model parameterized for an idealized preterm infant was developed to show the effect of high chest wall compliance on progressive lung volume loss. This earliest work was published <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0198425\">in PLoS One<\/a> in 2018.<\/li>\n<li>We recently developed a submodel of ribcage \/ abdominal mechanics to model thoracoabdominal asynchrony, or TAA (also called &#8220;chest retractions&#8221;). This work was published in <a href=\"https:\/\/journals.physiology.org\/doi\/abs\/10.1152\/ajplung.00123.2022\"><em>AJP &#8211; Lung Cellular and Molecular Physiology<\/em><\/a> in June 2023.<\/li>\n<li>We extended the foundational model to a data set from rat pups as part of the 2023 Collaborative Workshop for Women in Mathematical Biology. This work was published in the Springer Volume<br \/>\ntitled <a href=\"https:\/\/doi.org\/10.1007\/978-3-031-58516-6_6\">Mathematical Modeling for Women\u2019s Health &#8211; Collaborative Workshop for Women in Mathematical Biology<\/a> in 2024.<\/li>\n<li>The parameter space contributing to dynamics observed in the foundational model was analyzed in work published in 2025 in <a href=\"https:\/\/doi.org\/10.1098\/rsta.2024.0226\">Royal Society Philosophical Transactions A<\/a>.<\/li>\n<li>Recent efforts are focused on a bifurcation analysis related to the model\u2019s mechanical parameters. Possible additional opportunities include:\n<ul>\n<li>Incorporation of neural control as driver of model<\/li>\n<li>Addition of gas transport and chemoreflex response to breathing alterations<\/li>\n<li>Model effects of high frequency oscillation ventilation and\/or high flow nasal cannula<\/li>\n<li>Addition of stochastic components<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-573\" src=\"https:\/\/blogs.vcu.edu\/lellwein\/wp-content\/uploads\/sites\/287\/2023\/06\/11954231212059546365idea_yves_guillou_01.svg_.thumb_.png\" alt=\"\" width=\"24\" height=\"34\" \/>Modeling Cerebrovascular Reactivity in a Computer Model of Cardiorespiratory Dynamics<br \/>\n<\/strong>Students: Helen Harris, Mariana Fernandes Gragnani<\/p>\n<ul>\n<li>Cardiovascular disease and impaired cerebrovascular reactivity is often associated with impaired regulatory processes, but their interaction is not well understood. The goal of this project is to create a computer model of blood vessel resistance in the brain (cerebrovascular resistance, or CVR) that functionally depends on blood gas levels and blood pressure. This is an extension of <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0025556412001824\">published work from 2013<\/a> in which an empirical piecewise model of CVR was created within an existing closed-loop compartment model of the whole body circulatory system.\u00a0 Current efforts focus on developing an open-loop model dependent on blood pressure and gas levels based on previously published studies, and incorporate within the closed-loop whole body circulation model framework.<\/li>\n<li>This model is parameterized with continuous blood pressure, middle cerebral artery blood flow velocity, and expiratory CO2. This data is widely available for adults and we aim to incorporate such data in future studies to compare dynamics between groups of interest.<\/li>\n<\/ul>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-573\" src=\"https:\/\/blogs.vcu.edu\/lellwein\/wp-content\/uploads\/sites\/287\/2023\/06\/11954231212059546365idea_yves_guillou_01.svg_.thumb_.png\" alt=\"\" width=\"24\" height=\"34\" \/>Mathematical Modeling of Fluid Dynamics in an ECMO Oxygenator<br \/>\n<\/strong>Oliver Karam, MD\/PhD (Yale University)<\/p>\n<ul>\n<li>Extracorporeal Membrane Oxygenation (ECMO) is a life-saving procedure providing cardiac and respiratory support to patients with severe and potentially fatal heart or lung conditions. However, the possibility of clot formation within the oxygenator, a crucial component of the ECMO system, remains a significant concern. We are beginning to explore the development of a mathematical model of the fluid dynamics in an ECMO oxygenator to eventually predict personalized clotting risk in patients.<\/li>\n<\/ul>\n<p><strong>Designing a Novel Hypothalamic-Pituitary-Adrenal Axis Sensor System and Mathematical Modeling for Clinical Applications.<br \/>\n<\/strong>Benjamin Nicholson MD, David Chan, Ed Acevedo<br \/>\nStudent: Helen Harris<\/p>\n<ul>\n<li>The overall project goal is to develop a novel artificial adrenal system that incorporates a multi-analyte sensor system, a mathematical model for interpreting these hormones, and a hormone augmentation system to evaluate four hormones (cortisol, adrenocorticotropic hormone, epinephrine, and norepinephrine) during acute shock. The first manuscript from this project was reccently accept for publication in March 2026 in PLoS One.<\/li>\n<\/ul>\n<p><strong>Collaborative Research: A National Consortium for Synergistic Undergraduate Mathematics via Multi-Institutional Interdisciplinary Teaching Partnerships.<br \/>\n<\/strong>Multiple institutions. Rebecca Segal, Vennie Filippas, Hilary Clark (VCU).<\/p>\n<ul>\n<li>The overall project goal is to develop sustainable inter-institutional and inter-departmental collaborations that lead to improved outcomes in student transfer of knowledge from Mathematics to the partner discipline. Primary focus is on introductory Differential Equations.<\/li>\n<\/ul>\n<p><strong>Evaluation of Wall Shear Stress for Investigation of Restenosis in Stented Coronary Arteries Reconstructed Using Optical Coherence.<\/strong><br \/>\nJohn F. LaDisa, Jr., Marquette University; Hiromasa Otake MD, Kobe University Graduate School.<br \/>\nStudents: Ali Aleiou, Joshua Hughey<\/p>\n<ul>\n<li>The success of drug eluting stents is limited by restenosis and late stent thrombosis. Stenting as a common intervention alters artery geometry, exposing an artery to adverse wall shear stress (WSS). For DES it is not conclusively known if optimizing WSS leads to clinical benefits. The objective of this study is to determine the relationship between DES-induced WSS indices and two markers of poor outcomes, change in lumen area and category of stent malapposition.<\/li>\n<\/ul>\n<p style=\"text-align: left\"><strong>PAST PROJECTS<\/strong><\/p>\n<p><strong>Fluid dynamics analysis of\u00a0pulmonary\u00a0vasculature for understanding\u00a0pulmonary\u00a0arterial hypertension.<\/strong><br \/>\nMette Olufsen, NCSU; Umar Qureshi (postdoc), NCSU; Naomi Chesler, UC-Irvine; Nick Hill, University of Glasgow.<br \/>\nStudent: Mitchel Colebank<\/p>\n<p><strong>Translating Near Infrared Spectrocopy Oxygen Saturation Data for the Noninvasive Prediction of Spatial and Temporal Hemodynamics during Exercise.<\/strong><br \/>\nJohn F. LaDisa, Jr., Sheila Schindler-Ivens, and Michael Danduran, Marquette University; Margaret Samyn, Children\u2019s Hospital of Wisconsin.<\/p>\n<p><strong>Image-based Quantification Workflow for Coronary Morphology.<\/strong><br \/>\nJohn F. LaDisa, Jr., Marquette University; Raymond Migrino, VA Health Care System (Phoenix); David Marks, Medical College of Wisconsin.<\/p>\n<p><strong>Modeling Autoregulation in the Kidney<\/strong>.<br \/>\nAnita Layton, Duke; Julia Arciero, IUPUI; Ashlee Ford Versypt, University of Buffalo.<\/p>\n<p><strong>Cardiovascular and Respiratory Regulation, Modeling and Parameter Estimation<\/strong>. <a href=\"https:\/\/repository.lib.ncsu.edu\/handle\/1840.16\/3576\">PhD Thesis<\/a>.<br \/>\nAdvisor: Mette Olufsen, NCSU.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>INTERESTS Modeling of regulation in cardiovascular and pulmonary systems Differential equations and dynamical systems Data-driven patient-specific parameterization Numerical methods and optimization in physiological systems Algorithm development for biomedical applications Computational fluid dynamics GRANTS AND AWARDS Seed Award (VCU)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0 Apr\u00a0 2024 \u00a0\u00a0\u00a0 Predictive Modeling of Cerebrovascular Reactivity. PI: Laura Ellwein Fix.\u00a0Award: $5000 for student stipend [&hellip;]<\/p>\n","protected":false},"author":432,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/6","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/users\/432"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/comments?post=6"}],"version-history":[{"count":0,"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/pages\/6\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.vcu.edu\/lellwein\/wp-json\/wp\/v2\/media?parent=6"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}]