From Bench to Bedside: A Scientist’s Journey Through the K12 Program
Translating Basic Research into Therapeutic Tools
Entering the K12 program, Dr. Jiong Li, an Assistant Professor whose research focuses on understanding oncogenic signaling pathways and developing novel strategies for eradicating cancer, had a clear goal: to translate basic cancer research into therapeutic tools that could make a real impact on patient care. Recognizing the potential of the program to provide both training and support, Dr. Li sought to bridge the gap between discovery and application.
The journey wasn’t without its hurdles. Collaborating with mentors and navigating the inevitable obstacles of scientific inquiry tested both patience and resolve. One particularly memorable moment came when a reviewer’s critique led the team to reassess their approach. While initially disheartening, this process of reflection ultimately strengthened their research, yielding a more robust outcome. The experience highlighted the value of perseverance, ultimately leading to a well-regarded evaluation.
Dr. Li’s efforts have already borne fruit. In 2008-2009, he published a pivotal study identifying a crucial protein linked to cancer progression. While initially unsure how to translate this discovery into patient care, he’s since collaborated with medicinal chemists and structural biologists to develop small molecules targeting the protein. Supported by NIH funding, his team has made strides toward identifying new compounds and advancing preclinical and clinical research efforts. This milestone is particularly significant given Dr. Li’s limited background in drug discovery. Leveraging the collaborative environment at VCU, he has successfully navigated uncharted territory
The Power of Collaboration and Resources
When asked about the strategies that facilitated his success, Dr. Li emphasized the collaborative research environment at VCU. He described it as “very friendly and open to collaboration,” citing partnerships with medicinal chemists, cancer biologists, and immunology experts. The Massey Cancer Center’s extensive resources—including cancer models and genetic tools—enabled him to work more quickly and efficiently.
While much has been achieved, Dr. Li acknowledged one area for growth: strengthening collaborations with clinicians. However, progress is underway, as he’s begun to engage clinicians and pathologists as co-investigators, forming a more integrated research team.
Shaping the Future of Cancer Research
The K12 program’s impact on Dr. Li’s career trajectory is undeniable. The support has facilitated grant success, including short-term R21 awards and a new five-year grant. This longer-term funding has allowed for the expansion of the research team, larger experiments, and the adoption of new techniques. Looking forward, Dr. Li hopes to revive postponed projects, scaling up efforts with a more robust team.
Participation in the K12’s visiting scholar exchange program opened doors to new collaborations. Through visits to other institutions and hosting visiting scholars at VCU, Dr. Li established relationships with scientists at universities like Emory, leading to joint research initiatives.
The program’s training extended beyond the laboratory. Classes, seminars, and workshops in grant writing, mentoring, and other essential skills equipped Dr. Li with the tools needed to thrive. These learning opportunities complemented the hands-on mentorship that guided him through the complexities of translational research.
Future Impact on Health Outcomes
The ultimate goal is clear: to improve health outcomes for cancer patients. By identifying therapeutic targets and developing treatment strategies, Dr. Li’s work aims to enhance patient survival. While early-stage drug discovery is still underway, the potential for clinical application is within reach.
Currently focused on broad cancer research, Dr. Li envisions a more targeted approach in the future—possibly focusing on specific populations or cancer subtypes. He remains open to new collaborations, aware that working with diverse experts can amplify the impact of his work.
Pushing Boundaries with the K12 Program’s Support
The K12 program’s systematic training, mentorship, and emphasis on translational research have transformed Dr. Li’s approach. He’s learned to balance basic and translational research, with each informing and enhancing the other. This support system has been a catalyst for growth, enabling efficient research that has already garnered external recognition—including a prestigious four-year award from the American Cancer Society.
The role of mentorship cannot be overstated. Dr. Li credits his mentors’ experience and guidance as pivotal in boosting his research trajectory. This support system helped him secure significant grant funding, build collaborations, and enhance his research efficiency.
The K12 program has been a transformative experience for Dr. Jiong Li, enabling him to translate basic cancer research into tangible therapeutic pursuits. From forging new collaborations to mastering grant writing and mentorship, the skills and opportunities provided by the program have set the stage for continued success. With an eye on the future, Dr. Li is poised to make meaningful contributions to cancer treatment and patient care. His research into the Wnt/beta-catenin signaling pathway—a key driver of tumorigenesis—has been published in high-impact journals such as Nature Cell Biology, Cell Stem Cell, Nature Communications, Molecular Therapy, Cell Reports, and Oncogene, further demonstrating his impact in the field.
Categories K12, Mentorship, Research, Uncategorized